What's New

04/06/2018

Published an article "Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis" by S. Akila Parvathy Dharshini, Y-h. Taguchi and M. Michael Gromiha in Genomics.

Published an article "Deciphering RNA-Recognition Patterns of Intrinsically Disordered Proteins" by Ambuj Srivastava, Shandar Ahmad, and M. Michael Gromiha in International Journal of Molecular Sciences.
Published an article "Identification and analysis of key residues in protein—RNA complexes" by A. Kulandaisamy, Ambuj Srivastava, Pradeep Kumar, Nagarajan Raju and Dr. M. Michael Gromiha in IEEE/ACM Transactions on Computational Biology and Bioinformatics.

We congratulate Sherlyn Jemimah for Protein Science (sponsored by Wiley) Travel Award.
We welcome new members Dr. Dhanusha Yesudhas as a Research Associate and Priyadharshini Kannan as a Juniour Research Fellow.

We have released MutHTP, a database for Mutations in Human Transmembrane Proteins. It can be accessed here.

Published an article "Identification and analysis of key residues involved in folding and binding of protein-carbohydrate complexes. " by N.R. Siva Shanmugam, J. Fermin Angelo Selvin, K. Veluraja and M. Michael Gromiha. in Protein & Peptide Letters.

Published an article "MutHTP: Mutations in Human Transmembrane Proteins." by A. Kulandaisamy, S. Binny Priya, R. Sakthivel, S. Tarnovskaya, I. Bizin, P. Hönigschmid, D. Frishman and M. M. Gromiha in Bioinformatics.

An article "Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes" by Sherlyn Jemimah and M. Michael Gromiha has been accepted for publication in Proteins: Structure, Function, and Bioinformatics.

Published an article "Dissecting and analyzing key residues in protein-DNA complexes" by A. Kulandaisamy, A. Srivastava, R. Nagarajan, M. Michael Gromiha in Journal of Molecular Recognition.
Conducted 1^st Indo-Sweden discussion meeting on "Protein Bioinformatics and Deep Learning" on December 10-11,2017.
Conducted 4^th IIT Madras-Tokyo Tech Joint Symposium on "Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug Design" on November 10-11, 2017.

Dr. S. Selvaraj from Bharathidasan University visited our lab from 14 to 16 June, 2017.

One "Research Associate" and two "Junior Research Fellow" positions are available.

Received a research grant from the Council of Scientific and Industrial Research (CSIR), Government of India under Extramural Research Division for the project "Predictive modeling of nucleic acid recognition dynamics and structured complex formation by disordered proteins" during the period 2017-2019.

Published an article "PROXiMATE: A database of mutant protein-protein complex thermodynamics and kinetics." by Sherlyn Jemimah, K. Yugandhar, M. Michael Gromiha in Bioinformatics.
We have released PROXiMATE, a database of thermodynamic data for mutant protein heterodimer complexes collected from literature and previously published databases. It can be accessed here.

Published an article "Aggregation Propensity of Human Proteome: Insights from large-scale data analyses." by R. Prabakaran, D. Goel, S. Kumar and M. Michael Gromiha in Proteins.

Prof. Dr. Dimitrij Frishman from Technical University of Munich visited our lab from 13 to 16 Feb, 2017 under Indo-Russia bilateral research project funded by Department of Science and Technology (DST) and Russian Science Foundation (RSF).

Published a review article "Protein-protein interactions: scoring schemes and binding affinity." by M. Michael Gromiha, K. Yugandhar, and S. Jemimah (2016) in Current Opinion in Structural Biology.

Received a research grant from the Department of Science and Technology (DST), Government of India under Indo-Sweden bilateral program for the project "Deep learning for life sciences" during the period 2017-2019.

An article "Importance of functional groups in predicting the activity of small molecule inhibitors of Bcl-2 and Bcl-xL" by V. P. Kanakaveti, R. Sakthivel, Suresh K. Rayala and M. Michael Gromiha has been accepted in Chem. Biol. Drug Des. journal.
Published an article "Analysis of protein-protein interaction networks based on binding affinity" by K. Yugandhar and M. Michael Gromiha in Current Protein & Peptide Science.
Published an article "Important amino acid residues involved in folding and binding of protein-protein complexes" by A. Kulandaisamy, V. Lathi, K. Viswa Poorani, K. Yugandhar, and M. Michael Gromiha in International Journal of Biological Macromolecules.

Published an article "Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation and binding free energy calculation" by S. Anusuya and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics.