{"ligand_smiles": "", "ligand_id": "", "ligstr": "", "ligand_name": "", "global_stoichiometry": "Homo 12-mer - A12", "chain_id": "", "pmid": "7568160", "alternative_name": "", "pdb_classification": "IMMUNOGLOBULIN", "amyloid_non_amyloid": "Amyloid", "reference": "Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9490-4", "length": "108", "inchi_key": "", "pdb_id": "1BRE", "inchi": "", "type": "Fibril", "gene_names": "", "ligand_mw": "", "species": "Homo sapiens", "entry": "S-0011", "mutation_s_field": "No", "author": "Schormann, N., Murrell, J.R., Liepnieks, J.J., Benson, M.D.", "secondary_structure": "DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCEEEECSEEEECTTCCEEEEEEESSCCTTCEEEEECCTTSCCEEEEETTTEECTTSCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCEECCCEEEEECC&DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCEEEECSEEEECTTCCEEEEEEESSCCTTCCEEEEECTTSCCEEEEETTTEECTTCCTTEEEECCTTEEEEEESSCCGGGCSEEEEEECSSSSCEECCCEEEEECC&DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCEEEECSEECCSSSSEEEEEEEESSCCTTCCEEEECCTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEEESCCGGGCEEEEEBCCSSSSCCBCCCEEECCCC&DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCEEEECSEEEECTTCCEEEEEEESSCCTTCEEEEEECTTSCCEEEEETTTEECTTSCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCEEEEECC&DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCEEEECSEEECCTTSCEEEEEEESSCCTTCEEEEEECTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCCEEECCC&DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR#CCCCEEECSEEEECTTCCEEEEEECSSCCTTCEEEEEECTTSCCCEEEETTTEECSSCCTTEEEEESSSEEEEEESSCCGGGCSEEEEEECSSSSCCBCCCEEEEECC", "ec_number": "", "method": "X-RAY DIFFRACTION", "r_value_free": "0.337", "uniprot_ac": "", "resolution": "2.0", "description": "An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Comparison with a nonamyloid VL kappa domain from patient REI, identified significant differences in position of residues in the hypervariable segments plus variations in framework region (FR) segments 40-46 (FR2) and 66-67 (FR3). In addition, positional differences can be seen along the two types of local diads, corresponding to the monomer-monomer and dimer-dimer interfaces. From the packing diagram, a model for the amyloid light chain (AL) fibril is proposed based on a pseudohexagonal spiral structure with a rise of approximately the width of two dimers per 360 degree turn. This spiral structure could be consistent with the dimensions of amyloid fibrils as determined by electron microscopy.", "peptide_protein_sequence": "chain-ID A: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR; chain-ID B: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR; chain-ID C: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR; chain-ID D: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR; chain-ID E: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR; chain-ID F: DIQMTQSPSSLSASVGDRVTITCQASQDISDYLIWYQQKLGKAPNLLIYDASTLETGVPSRFSGSGSGTEYTFTISSLQPEDIATYYCQQYDDLPYTFGQGTKVEIKR", "protein_name": "IMMUNOGLOBULIN LIGHT CHAIN PROTEIN (kappa I)", "keyword": "BENCE-JONES KAPPA I PROTEIN BRE", "remarks": "An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis", "ligand_formula": ""}