{"ligand_smiles": "", "ligand_id": "", "ligstr": "", "ligand_name": "", "global_stoichiometry": "Homo 4-mer - A4 ", "chain_id": "", "pmid": "9818054", "alternative_name": "ATTR, Prealbumin, TBPA", "pdb_classification": "BINDING PROTEIN", "amyloid_non_amyloid": "Non-amyloid", "reference": "Amyloid. 1998 Sep;5(3):175-87", "length": "127", "inchi_key": "", "pdb_id": "1BZD", "inchi": "", "type": "Protein", "gene_names": "TTR, PALB", "ligand_mw": "", "species": "Homo sapiens", "entry": "S-0012", "mutation_s_field": "G6S", "author": "Schormann, N., Murrell, J.R., Benson, M.D.", "secondary_structure": "GPTGTSESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE#CCCSSSCSSCSEEEEEEETTTTEECCSCEEEEEEEETTTEEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSEEEEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC&GPTGTSESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE#CCBCSCCCSCSEEEEEEETTTTEECTTCEEEEEEECTTSCEEEEEEEECCTTSEEBCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSBSCEEEEEEECSSSCSEEEEEEEEETTEEEEEEEEESSCC", "ec_number": "", "method": "X-RAY DIFFRACTION", "r_value_free": "0.265", "uniprot_ac": "P02766", "resolution": "1.9", "description": "They reported crystallization and structural investigations of three amyloidogenic (Arg10, Ala60, Tyr77) and two non-amyloidogenic variants (Ser6, Met119). The similarity of these structures to normal transthyretin does not give direct clues to the fibril forming process. All amyloidogenic variants show an increased main chain solvent exposure when compared to normal transthyretin and non-amyloidogenic variants, which can be postulated to result in increased susceptibility to proteolysis.", "peptide_protein_sequence": "chain-ID A: GPTGTSESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE; chain-ID B: GPTGTSESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE", "protein_name": "Transthyretin", "keyword": "PROTEIN (TRANSTHYRETIN)", "remarks": "TERTIARY STRUCTURES OF AMYLOIDOGENIC TRANSTHYRETIN VARIANTS", "ligand_formula": ""}