{"uniprot_ac": "P02766", "ligand_formula": "", "pdb_classification": "BINDING PROTEIN", "amyloid_non_amyloid": "Non-amyloid", "ligand_smiles": "", "protein_name": "Transthyretin", "type": "Protein", "inchi_key": "", "remarks": "TERTIARY STRUCTURES OF AMYLOIDOGENIC TRANSTHYRETIN VARIANTS", "method": "X-RAY DIFFRACTION", "global_stoichiometry": "Homo 4-mer - A4 ", "inchi": "", "ligand_id": "", "entry": "S-0013", "keyword": "PROTEIN (TRANSTHYRETIN)", "mutation_s_field": "T119M", "peptide_protein_sequence": "chain-ID A: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTMAVVTNPKE; chain-ID B: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTMAVVTNPKE", "reference": "Amyloid. 1998 Sep;5(3):175-87", "description": "They reported crystallization and structural investigations of three amyloidogenic (Arg10, Ala60, Tyr77) and two non-amyloidogenic variants (Ser6, Met119). The similarity of these structures to normal transthyretin does not give direct clues to the fibril forming process. All amyloidogenic variants show an increased main chain solvent exposure when compared to normal transthyretin and non-amyloidogenic variants, which can be postulated to result in increased susceptibility to proteolysis.", "ec_number": "", "gene_names": "TTR, PALB", "ligand_name": "", "chain_id": "", "pmid": "9818054", "author": "Schormann, N., Murrell, J.R., Benson, M.D.", "r_value_free": "0.273", "species": "Homo sapiens", "length": "127", "secondary_structure": "GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTMAVVTNPKE#CCCTTSCSSCSEEEEEEETTTTEECTTCEEEEEEECTTSSEEEEEEEECCTTSEECCSCCTTTSCSEEEEEEECHHHHHHHTTCCCSBSCEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC&GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTMAVVTNPKE#CCCCSCSSSCCEEEEEEETTTTEECCSCEEEEEEECTTCCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSBSCEEEEEEECSSSCSEEEEEEEEETTEEEEEEEEESSCC", "ligstr": "", "resolution": "1.8", "ligand_mw": "", "pdb_id": "1BZE", "alternative_name": "ATTR, Prealbumin, TBPA"}