{"ligand_smiles": "[Cl-]%%C(C(CO)O)O", "ligand_id": "CL%%GOL", "ligstr": "CL:A:Cl -1:35.45:CHLORIDE ION:[Cl-]:InChI=1S/ClH/h1H/p-1:VEXZGXHMUGYJMC-UHFFFAOYSA-M;GOL:A:C3 H8 O3:92.09:GLYCEROL:C(C(CO)O)O:InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2:PEDCQBHIVMGVHV-UHFFFAOYSA-N", "ligand_name": "CHLORIDE ION%%GLYCEROL", "global_stoichiometry": "Homo 2-mer - A2 ", "chain_id": "A%%A", "pmid": "11276250", "alternative_name": "Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin", "pdb_classification": "hydrolase inhibitor", "amyloid_non_amyloid": "Amyloid", "reference": "Nat Struct Biol. 2001 Apr;8(4):316-20", "length": "120", "inchi_key": "VEXZGXHMUGYJMC-UHFFFAOYSA-M%%PEDCQBHIVMGVHV-UHFFFAOYSA-N", "pdb_id": "1G96", "inchi": "InChI=1S/ClH/h1H/p-1%%InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2", "type": "Protein", "gene_names": "CST3", "ligand_mw": "35.45%%92.09", "species": "Homo sapiens", "entry": "S-0029", "mutation_s_field": "No", "author": "Janowski, R., Kozak, M., Jankowska, E., Grzonka, Z., Grubb, A., Abrahamson, M., Jaskolski, M.", "secondary_structure": "SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCCCCCCCCCSCEECCSCSHHHHHHHHHHHHHHHHHCCCSSCCCCSCCCCCEECCCCCEEEEEEEEEECBSCCTTSSCGGGCCBCCSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC", "ec_number": "", "method": "X-RAY DIFFRACTION", "r_value_free": "0.249", "uniprot_ac": "P01034", "resolution": "2.5", "description": "human cystatin C protein refolds to produce very tight two-fold symmetric dimers while retaining the secondary structure of the monomeric form. The dimerization occurs through three-dimensional domain swapping, a mechanism for forming oligomeric proteins.  The tendency of human cystatin C to dimerize and suggests a mechanism for its aggregation in the brain arteries of elderly people with amyloid angiopathy. ", "peptide_protein_sequence": "chain-ID A: SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA", "protein_name": "Cystatin-C", "keyword": "CYSTATIN C", "remarks": "Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping", "ligand_formula": "Cl -1%%C3 H8 O3"}