{"entry": "S-0030", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE; chain-ID B: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE; chain-ID C: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE; chain-ID D: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE", "remarks": "An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured, Low pH", "pmid": "11560492", "chain_id": "", "mutation_s_field": "F87M/L110M", "ligstr": "", "r_value_free": "0.26899999", "uniprot_ac": "P02766", "resolution": "2.1", "pdb_id": "1GKO", "protein_name": "Transthyretin", "gene_names": "TTR, PALB", "species": "Homo sapiens", "method": "X-RAY DIFFRACTION", "author": "Jiang, X., Smith, C.S., Petrassi, H.M., Hammarstrom, P., White, J.T., Sacchettini, J.C., Kelly, J.W.", "type": "Protein", "ligand_mw": "", "secondary_structure": "GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECTTCEEEEEEECSSSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSBSCEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC&GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECTTCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSBCCEEEEEEESTTSCCCEEEEEEEETTEEEEEEEECCCCC&GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECTTCEEEEEEECSSSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHTTTCCCSBSCEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC&GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAAMLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHTTTCCCSBCCEEEEEEESTTSCCCEEEEEEEETTEEEEEEEECCCCC", "description": "To understand whether tertiary structural changes are required for amyloidogenicity, Phe87Met/Leu110Met TTR variant (M-TTR) was created that is non-amyloidogenic at neutral pH. M-TTR forms a tertiary structure at pH 7 that is very similar if not identical to that found within the tetramer. Reducing the pH results in tertiary structural changes within the M-TTR monomer, rendering it amyloidogenic, demonstrating the requirement for partial denaturation.", "ec_number": "", "global_stoichiometry": "Homo 2-mer - A2", "ligand_name": "", "ligand_id": "", "pdb_classification": "TRANSPORT(THYROXINE)", "length": "127", "keyword": "TRANSTHYRETIN", "amyloid_non_amyloid": "Amyloid", "inchi": "", "reference": "Biochemistry. 2001 Sep 25;40(38):11442-52", "alternative_name": "ATTR, Prealbumin, TBPA", "ligand_smiles": "", "inchi_key": ""}