{"reference": "J Biochem. 2002 Oct;132(4):655-61", "alternative_name": "1, 4-beta-N-acetylmuramidase C", "entry": "S-0036", "gene_names": "LYZ, LZM", "remarks": "Elongation in a beta-Structure Promotes Amyloid-Like Fibril Formation of Human Lysozyme", "secondary_structure": "EAEAKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGTFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV#CCCCCBCCHHHHHHHHHHTTCTTGGGCCHHHHHHHHHHHHTTBTTCEEEETTTTEEEETTTTEETTTTSBCSCSTTCCCTTCSBGGGGGSSSCHHHHHHHHHHTTSTTGGGGCHHHHHHTTTSCCGGGTTTSCC", "chain_id": "A", "inchi": "InChI=1S/Na/q+1", "amyloid_non_amyloid": "Amyloid", "pmid": "12359083", "ligand_smiles": "[Na+]", "keyword": "LYSOZYME C", "peptide_protein_sequence": "chain-ID A: EAEAKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGTFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV", "uniprot_ac": "P61626", "protein_name": "Lysozyme C", "r_value_free": "", "mutation_s_field": "EAEA (insert at N-terminal)-I56T", "ligand_mw": "22.99", "pdb_id": "1IOC", "inchi_key": "FKNQFGJONOIPTF-UHFFFAOYSA-N", "ec_number": "3.2.1.17", "pdb_classification": "HYDROLASE", "type": "Protein", "author": "Goda, S., Takano, K., Yamagata, Y., Maki, S., Namba, K., Yutani, K.", "species": "Homo sapiens", "ligand_id": "", "method": "X-RAY DIFFRACTION", "ligand_name": "SODIUM ION", "global_stoichiometry": "Monomer - A", "resolution": "2.4", "ligand_formula": "Na 1", "length": "134", "ligstr": "", "description": "human lysozymes proteins: wild-type; I56T (amyloidogenic); EAEA (which has four additional residues Glu-Ala-Glu-Ala-) at the N-terminus located on a Beta-structure; and EAEA-I56T, which is an I56T mutant of EAEA. All formed amyloid-like fibrils through an in the increase contents of Alpha-helix with increasing concentration of ethanol. The order of propensity for amyloid-like fibril formation in highly concentrated ethanol solution is EAEA-I56T > EAEA > I56T > wild-type. This order is almost the reverse of the order of conformational stability of these proteins, wild-type > EAEA > I56T > EAEA-I56T."}