{"method": "SOLUTION NMR", "mutation_s_field": "No", "ec_number": "", "description": "Compared to previous structural data obtained from the NMR secondary structure of the isolated protein and the crystal structure of MHC-I, in which the protein is associated to the heavy-chain component, several differences are observed. The most important rearrangements were observed for (1) strands V and VI (loss of the C-terminal and N-terminal end, respectively), (2) interstrand loop V-VI, and (3) strand I, including the N-terminal segment (displacement outward of the molecular core). These modifications can be considered as the prodromes of the amyloid transition. Solvation of the protected regions in MHC-I decreases the tertiary packing by breaking the contiguity of the surface hydrophobic patches at the interface with heavy chain and the nearby region at the surface charge cluster of the C-terminal segment. ", "ligstr": "", "pmid": "11847272", "remarks": "The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "", "resolution": "", "species": "Homo sapiens", "secondary_structure": "MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCBCCEEEEEESSCCCSSSCCCEEEEEESCBSSCEECCEECSSCEECCCEECCCCCTTTTCCCEEEEECCCCCTTCCCEEEEEETTCSSCEEEECCCCC", "chain_id": "", "gene_names": "B2M, CDABP0092, HDCMA22P", "r_value_free": "", "pdb_id": "1JNJ", "reference": "Protein Sci. 2002 Mar;11(3):487-99", "keyword": "beta2-microglobulin", "protein_name": "Beta-2-microglobulin", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM", "entry": "S-0038", "length": "100", "uniprot_ac": "P61769", "author": "Verdone, G., Corazza, A., Viglino, P., Pettirossi, F., Giorgetti, S., Mangione, P., Andreola, A., Stoppini, M., Bellotti, V., Esposito, G.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "IMMUNE SYSTEM", "global_stoichiometry": "Monomer - A", "inchi_key": "", "ligand_id": ""}