{"reference": "Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):815-23. Epub  2002 Apr 26", "alternative_name": "", "entry": "S-0039", "gene_names": "", "remarks": "THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR", "secondary_structure": "ETALTQPASVSGSPGQSITVSCTGVSSIVGSYNLVSWYQQHPGKAPKLLTYEVNKRPSGVSDRFSGSKSGNSASLTISGLQAEDEADYYCSSYDGSSTSVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTAC#CCCBBCCSEEEECTTCEEEEEEECCCCSSTTCCCEEEEEECTTSCCEEEEBTTTBCCTTSCTTEEEEEETTEEEEEEESCCGGGCEEEEEEESCSSSSCCEEBCCEEEEECCCCCBCCEEEEECCCHHHHHTTCEEEEEEEEEEBSSCCEEEEEETTEECCSSEEECCCEECTTSCEEEEEEEEECHHHHHTSSCEEEEEEETTEEEEEEECCCCC&ETALTQPASVSGSPGQSITVSCTGVSSIVGSYNLVSWYQQHPGKAPKLLTYEVNKRPSGVSDRFSGSKSGNSASLTISGLQAEDEADYYCSSYDGSSTSVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTAC#CCSCBCCSEEEECTTCCEEEEEECTTTSTTCTTCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEEETTTTEEEECCCEEEEECSSCCBCCEEEEECCCHHHHHTTCEEEEEEEEEEBSSCCEEEEESSSSEECSSEEECCCEECTTSSEEEEEEEEECHHHHHHCSCEEEEEEETTEEEEEEECSCCC", "chain_id": "A%%B", "inchi": "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1%%InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1", "amyloid_non_amyloid": "Amyloid", "pmid": "11976493", "ligand_smiles": "C1CC(=O)N[C@@H]1C(=O)O%%C1CC(=O)N[C@@H]1C(=O)O", "keyword": "IMMUNOGLOBULIN LAMBDA LIGHT CHAIN", "peptide_protein_sequence": "chain-ID A: ETALTQPASVSGSPGQSITVSCTGVSSIVGSYNLVSWYQQHPGKAPKLLTYEVNKRPSGVSDRFSGSKSGNSASLTISGLQAEDEADYYCSSYDGSSTSVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTAC; chain-ID B: ETALTQPASVSGSPGQSITVSCTGVSSIVGSYNLVSWYQQHPGKAPKLLTYEVNKRPSGVSDRFSGSKSGNSASLTISGLQAEDEADYYCSSYDGSSTSVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTAC", "uniprot_ac": "Q6PJG0", "protein_name": "Uncharacterized protein", "r_value_free": "0.254", "mutation_s_field": "No", "ligand_mw": "129.11%%129.11", "pdb_id": "1JVK", "inchi_key": "ODHCTXKNWHHXJC-VKHMYHEASA-N%%ODHCTXKNWHHXJC-VKHMYHEASA-N", "ec_number": "", "pdb_classification": "IMMUNE SYSTEM", "type": "Protein", "author": "Bourne, P.C., Ramsland, P.A., Shan, L., Fan, Z.C., DeWitt, C.R., Shultz, B.B., Terzyan, S.S., Moomaw, C.R., Slaughter, C.A., Guddat, L.W., Edmundson, A.B.", "species": "Homo sapiens", "ligand_id": "PCA%%PCA", "method": "X-RAY DIFFRACTION", "ligand_name": "PYROGLUTAMIC ACID%%PYROGLUTAMIC ACID", "global_stoichiometry": "Homo 2-mer - A2", "resolution": "1.94", "ligand_formula": "C5 H7 N O3%%C5 H7 N O3", "length": "216", "ligstr": "PCA:A:C5 H7 N O3:129.11:PYROGLUTAMIC ACID:C1CC(=O)N[C@@H]1C(=O)O:InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1:ODHCTXKNWHHXJC-VKHMYHEASA-N;PCA:B:C5 H7 N O3:129.11:PYROGLUTAMIC ACID:C1CC(=O)N[C@@H]1C(=O)O:InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1:ODHCTXKNWHHXJC-VKHMYHEASA-N", "description": "\"The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a \"\"Bence-Jones protein\"\" from a patient with multiple myeloma and amyloidosis (Sea). The urinary protein produced fibrillar amyloid deposits which were fatal to the patient. Compared with the amyloidogenic Mcg light-chain dimer, the Sea protein was highly soluble in aqueous solutions and only crystallized at concentrations approaching 100 mg ml(-1).\""}