{"resolution": "", "ligand_mw": "", "secondary_structure": "SNNFGAILSS#CCSSSSTTTC", "inchi": "", "method": "SOLUTION NMR", "ec_number": "", "uniprot_ac": "P10997", "remarks": "Conformational preferences of the amylin nucleation site in SDS micelles", "description": "hIAPP constitutes approximately 90% of the amyloid deposits found in type II diabetic patients. It has been shown that the central region of the peptide (hIAPP(20-29)) constitutes the nucleation site for the amyloidogenic process with F23 playing a key role in the formation of the Beta-pleated structures.", "type": "Peptide", "ligand_smiles": "", "chain_id": "", "species": "Homo sapiens", "keyword": "Islet amyloid polypeptide", "ligstr": "", "pmid": "12717720", "mutation_s_field": "No", "author": "Mascioni, A., Porcelli, F., Ilangovan, U., Ramamoorthy, A., Veglia, G.", "pdb_id": "1KUW", "amyloid_non_amyloid": "Amyloid", "inchi_key": "", "ligand_name": "", "ligand_formula": "", "ligand_id": "", "r_value_free": "", "protein_name": "Islet amyloid polypeptide", "gene_names": "", "global_stoichiometry": "", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: SNNFGAILSS", "pdb_classification": "HORMONE/GROWTH FACTOR", "reference": "Biopolymers. 2003 May;69(1):29-41", "length": "10", "entry": "S-0040"}