{"method": "X-RAY DIFFRACTION", "mutation_s_field": "D67H", "ec_number": "3.2.1.17", "description": "The naturally occurring human lysozyme variants is amyloidogenic, and shown here to be unstable. This aggregates to form amyloid fibrils with transformation of the mainly helical native fold, observed in crystal structures, to the amyloid fibril cross-Beta fold. Biophysical studies suggest that partly folded intermediates are involved in fibrillogenesis", "ligstr": "", "pmid": "9039909", "remarks": "AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "", "resolution": "1.8", "species": "Homo sapiens", "secondary_structure": "KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNHGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV#CBCCHHHHHHHHHHTTCTTBTTBCHHHHHHHHHHHHTTBTTCEEEETTTTEEEETTTTEETTTTSBSTTCTTCCCTTCSBGGGGGSSSCHHHHHHHHHHHTSTTGGGGSHHHHHHTTTSCCGGGSTTSCC", "chain_id": "", "gene_names": "LYZ, LZM", "r_value_free": "", "pdb_id": "1LYY", "reference": "Nature. 1997 Feb 27;385(6619):787-93", "keyword": "LYSOZYME", "protein_name": "Lysozyme C", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNHGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV", "entry": "S-0043", "length": "130", "uniprot_ac": "P61626", "author": "Booth, D.R., Sunde, M., Bellotti, V., Robinson, C.V., Hutchinson, W.L., Fraser, P.E., Hawkins, P.N., Dobson, C.M., Radford, S.E., Blake, C.C., Pepys, M.B.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "1, 4-beta-N-acetylmuramidase C", "ligand_name": "", "pdb_classification": "HYDROLASE", "global_stoichiometry": "Monomer - A ", "inchi_key": "", "ligand_id": ""}