{"global_stoichiometry": "Monomer - A", "ligstr": "", "uniprot_ac": "P08592", "inchi": "", "reference": "J Biol Inorg Chem. 2004 Jul;9(5):627-35. Epub  2004 May 25", "author": "Huang, J., Yao, Y., Lin, J., Ye, Y.H., Sun, W.Y., Tang, W.X.", "type": "Peptide", "ligand_id": "", "species": "Rattus norvegicus", "method": "SOLUTION NMR", "keyword": "amyloid beta-peptide from Alzheimer's disease amyloid A4 protein homolog", "gene_names": "App", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "DAEFGHDSGFEVRHQKLVFFAEDVGSNK#CCCCCSSTTTTTTTTHHHHHHHHHCCCC", "amyloid_non_amyloid": "Non-amyloid", "length": "28", "remarks": "The Solution Structure of Rat Ab-(1-28) and its Interaction with Zinc: Insights into the Scarity of Amyloid Deposition in Aged Rat Brain", "protein_name": "Amyloid-beta A4 protein", "peptide_protein_sequence": "chain-ID A: DAEFGHDSGFEVRHQKLVFFAEDVGSNK", "ligand_name": "", "ligand_smiles": "", "pdb_id": "1NMJ", "ec_number": "", "pdb_classification": "MEMBRANE PROTEIN", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "", "alternative_name": "ABPP, Alzheimer disease amyloid A4 protein homolog, Amyloid precursor protein, Amyloid-beta precursor protein, Amyloidogenic glycoprotein", "description": "The three-dimensional solution structure of rat ABeta-(1-28) is more stable than that of human ABeta-(1-28) in DMSO- d(6) and helical region from Glu16 to Val24 exists in the rat ABeta-(1-28). The affinity of Zn(2+) for rat ABeta-(1-28) is lower than that for human ABeta-(1-28) and the NMR data suggest that Arg13, His6, and His14 residues provide the primary binding sites for Zn(2+). The proper binding of Zn(2+) to rat ABeta-(1-28) can induce the peptide to change to a more stable conformation.", "resolution": "", "pmid": "15160315", "entry": "S-0045"}