{"method": "X-RAY DIFFRACTION", "mutation_s_field": "H31Y ", "ec_number": "", "description": "the His31Tyr human Beta2m mutant, a non-natural form of Beta2m that is more stable than the wild-type protein, displaying a ten-fold acceleration of the slow phase of folding, was characterized. Juxtaposition of the four mutant Beta2m molecules contained in the crystal asymmetric unit, and specific hydrogen bonds, stabilize a compact protein assembly. Conformational heterogeneity of the four independent molecules, some of their mutual interactions and partial unpairing of the N-terminal Beta-strand in one protomer are in keeping with the amyloidogenic properties displayed by the mutant Beta2m.", "ligstr": "", "pmid": "14698299", "remarks": "Beta2 microglobulin mutant H31Y displays hints for amyloid formations", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "", "resolution": "2.9", "species": "Homo sapiens", "secondary_structure": "MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCBCCEEEEEESSCCCTTSCCEEEEEEEEEBSCCEEEEEEESSCBCSCCEECCEEEETTTEEEEEEEEECCCCSSCCEEEEEEETTSSSCEEEECCCCC&MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCBCCEEEEEESSCCCTTSCEEEEEEEEEEBSCCCEEEEEETTEECSCCEECCCEEETTTEEEEEEEEEECCCSSCCEEEEEECTTSSSCEEEECCCCC&MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCBCCEEEEECSSCCCTTCCEEEEEEEESCBSSCEEEEEEETTEEESCCBCCCCEECSTTCEEEEEEEEECCCTTCCEEEEEEETTCSSCEEECCCCCC&MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCBCCCCCCCCSSSTTTTSCCBCCCCEEEEBSSCCBCCCBSSSSBCSSCEECCEEEETTTEEEECEECBCCCCSSSCCCCBCBCTTCSSCCBCCCCCCC", "chain_id": "", "gene_names": "B2M, CDABP0092, HDCMA22P", "r_value_free": "0.313", "pdb_id": "1PY4", "reference": "J Mol Biol. 2004 Jan 23;335(4):1051-64", "keyword": "Beta-2-microglobulin precursor", "protein_name": "Beta-2-microglobulin", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM; chain-ID B: MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM; chain-ID C: MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM; chain-ID D: MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM", "entry": "S-0051", "length": "100", "uniprot_ac": "P61769", "author": "Rosano, C., Zuccotti, S., Mangione, P., Giorgetti, S., Bellotti, V., Pettirossi, F., Corazza, A., Viglino, P., Esposito, G., Bolognesi, M.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "SIGNALING PROTEIN", "global_stoichiometry": "Monomer - A", "inchi_key": "", "ligand_id": ""}