{"global_stoichiometry": "Homo 2-mer - A2", "ligstr": "", "uniprot_ac": "P01034", "inchi": "", "reference": "J Mol Biol. 2004 Jul 30;341(1):151-60", "author": "Janowski, R., Abrahamson, M., Grubb, A., Jaskolski, M.", "type": "Protein", "ligand_id": "", "species": "Homo sapiens", "method": "X-RAY DIFFRACTION", "keyword": "Cystatin C", "gene_names": "CST3", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTSHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTSSCGGGCCBCCSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTSHHHHHHHHHHHHHHHHHSCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTCSSCSCSCBCCSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTSHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTSSCGGGCCBCCSTTTCCEEEEEEEEEEETTTTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTSHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTCSCGGGCCBCCSTTTCCEEEEEEEEEEETTTTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTSHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESSSSCCSSCCBCCSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCSSSHHHHHHHHHHHHHHHHHSCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTSSSGGGCCBCCSTTTCCEEEEEEEEEEETTTTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCSEECCTTSHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTCSCCSSCCBCCSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC&GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCEECCTTCHHHHHHHHHHHHHHHHHCCCSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTCSCCSSCCBCCSGGGSCCEEEEEEEEEEGGGTEEEEEEEEEEEC", "amyloid_non_amyloid": "Amyloid", "length": "110", "remarks": "Naturally occurring Leu68Gln variant in N-truncated human cystatin C, resulting in fatal amyloidosis in early adult life", "protein_name": "Cystatin-C", "peptide_protein_sequence": "chain-ID A: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID B: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID C: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID D: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID E: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID F: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID G: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID H: GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA", "ligand_name": "", "ligand_smiles": "", "pdb_id": "1R4C", "ec_number": "", "pdb_classification": "HYDROLASE INHIBITOR", "mutation_s_field": "L68Q, 10 residue truncated fron N-terminal", "ligand_formula": "", "r_value_free": "0.259", "alternative_name": "Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin", "description": "When proteins are extracted from human cystatin C amyloid deposits, an N-terminally truncated cystatin C (THCC) is found, lacking the first ten amino acid residues of the native sequence. It has been shown that the cerebrospinal fluid may cause this N-terminal truncation. The structure reveals dimerization by domain swapping. However, the new crystal structure is composed of four independent HCC dimers, none of which has the exact 2-fold symmetry of the full-length dimer. While the four dimers have the same overall topology as the full length protein.", "resolution": "2.18", "pmid": "15312769", "entry": "S-0059"}