{"method": "X-RAY DIFFRACTION", "mutation_s_field": "L68Q, truncated fron N-terminal", "ec_number": "", "description": "Oligomerization of human cystatin C (HCC) leads to amyloid deposits in brain arteries, and this process is greatly accelerated with a naturally occurring L68Q variant. The crystal structures of N-truncated and full-length HCC showed dimer formation via (3D) domain swapping which could be the basis of HCC fibril formation.", "ligstr": "", "pmid": "16170782", "remarks": "3D Domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "", "resolution": "3.03", "species": "Homo sapiens", "secondary_structure": "SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCCCCCCSSCCCEECCTTCHHHHHHHHHHHHHHHHTCSSSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESSCSCCSCCCBCCSTTTCCEEEEEEEEEEETTTTEEEEEEEEEECC&SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA#CCCCCCCCCEEEEEECCTTCHHHHHHHHHHHHHHHHHCSSSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESSCSCCSCCCBCSSTTTCCEEEEEEEEEEEGGGTEEEEEEEEEEEC", "chain_id": "", "gene_names": "CST3", "r_value_free": "0.262", "pdb_id": "1TIJ", "reference": "Proteins. 2005 Nov 15;61(3):570-8", "keyword": "Cystatin C", "protein_name": "Cystatin-C", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA; chain-ID B: SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA", "entry": "S-0064", "length": "120", "uniprot_ac": "P01034", "author": "Janowski, R., Kozak, M., Abrahamson, M., Grubb, A., Jaskolski, M.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin", "ligand_name": "", "pdb_classification": "HYDROLASE INHIBITOR", "global_stoichiometry": "Homo 2-mer - A2 ", "inchi_key": "", "ligand_id": ""}