{"resolution": "2.8", "ligand_mw": "", "secondary_structure": "MKIAGIDEAGRGPVIGPMVIAAVVVDENSLPKLEELKVRDSKKLTPKRREKLFNEILGVLDDYVILELPPDVIGSREGTLNEFEVENFAKALNSLKVKPDVIYADAADVDEERFARELGERLNFEAEVVAKHKADDIFPVVSAASILAKVTRDRAVEKLKEEYGEIGSGYPSDPRTRAFLENYYREHGEFPPIVRKGAGAIIGLAVGGVVIA#CEEEEEEEECSSCSSSCEEEEEEEEETTTHHHHHHTTGGGTTTSCHHHHHHHHHHHHHHCSEEEEEEECCCCTTCSCTTCTTTHHHHHHHHHTTCSSCCSEEEEEECSSCHHHHHHHHHHHSSSCCEEEEEETTTTTCHHHHHHHHHHHHHHHHHHHHHHHHHSCCTTSSTTCHHHHHHHHHHHHTTSSCCTTSCCCSCCCCCEETTEECCC", "inchi": "", "method": "X-RAY DIFFRACTION", "ec_number": "3.1.26.4", "uniprot_ac": "O74035", "remarks": "Crystal structure of Tk-RNase HII(1-197)-A(28-42)", "description": "\"\"\"Crystal structure of Tk-RNase HII(1-197)-A(28-42)\"\". The atomic-level structure of ABeta(28-42) in an aqueous environment. The fragments of ABeta, residues 10-24 or 28-42 were fused to three positions in the C-terminal region of ribonuclease HII from a hyperthermophile (Tk-RNase HII) and examined for structural properties in an aqueous environment. Tk-RNase HII is highly stable and the C-terminal region has relatively little interaction with other parts. The guest amyloidogenic sequences did not affect the overall structure of the Tk-RNase HII. Crystal structure analysis of Tk-RNase HII(1-197)-ABeta(28-42) revealed that ABeta(28-42) forms a Beta conformation, whereas the original structure in Tk-RNase HII(1-213) was Alpha helix, suggesting Beta-structure formation of ABeta(28-42) within full-length ABeta in aqueous solution. ABeta(28-42) enhanced aggregation of the host protein more strongly than ABeta(10-24).\"", "type": "Aggregating complex", "ligand_smiles": "", "chain_id": "", "species": "Thermococcus kodakarensis", "keyword": "Ribonuclease HII", "ligstr": "", "pmid": "16367755", "mutation_s_field": "No", "author": "Takano, K., Endo, S., Mukaiyama, A., Chon, H., Matsumura, H., Koga, Y., Kanaya, S.", "pdb_id": "1X1P", "amyloid_non_amyloid": "Amyloid", "inchi_key": "", "ligand_name": "", "ligand_formula": "", "ligand_id": "", "r_value_free": "0.3", "protein_name": "Ribonuclease HII", "gene_names": "rnhB, TK0805", "global_stoichiometry": "Monomer - A ", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: MKIAGIDEAGRGPVIGPMVIAAVVVDENSLPKLEELKVRDSKKLTPKRREKLFNEILGVLDDYVILELPPDVIGSREGTLNEFEVENFAKALNSLKVKPDVIYADAADVDEERFARELGERLNFEAEVVAKHKADDIFPVVSAASILAKVTRDRAVEKLKEEYGEIGSGYPSDPRTRAFLENYYREHGEFPPIVRKGAGAIIGLAVGGVVIA", "pdb_classification": "HYDROLASE", "reference": "FEBS J. 2006 Jan;273(1):150-8", "length": "212", "entry": "S-0070"}