{"reference": "Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):333-9. Epub  2005 Feb 24", "alternative_name": "ATTR, Prealbumin, TBPA", "entry": "S-0071", "gene_names": "TTR, PALB", "remarks": "The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe", "secondary_structure": "GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSFWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSEEEEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC&GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSFWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHHTCCCSEEEEEEEEEECCCCCCCEEEEEEEETTEEEEEEEECCCCC", "chain_id": "", "inchi": "", "amyloid_non_amyloid": "Amyloid", "pmid": "15735344", "ligand_smiles": "", "keyword": "Transthyretin", "peptide_protein_sequence": "chain-ID A: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSFWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE; chain-ID B: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSFWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE", "uniprot_ac": "P02766", "protein_name": "Transthyretin", "r_value_free": "0.23800000", "mutation_s_field": "Y78F", "ligand_mw": "", "pdb_id": "1X7S", "inchi_key": "", "ec_number": "", "pdb_classification": "TRANSPORT PROTEIN", "type": "Protein", "author": "Neto-Silva, R.M., Macedo-Ribeiro, S., Pereira, P.J., Coll, M., Saraiva, M.J., Damas, A.M.", "species": "Homo sapiens", "ligand_id": "", "method": "X-RAY DIFFRACTION", "ligand_name": "", "global_stoichiometry": "Homo 4-mer - A4 ", "resolution": "1.55", "ligand_formula": "", "length": "127", "ligstr": "", "description": "The analysis of the protein model for TTR Y78F indicates a destabilization of the contacts between the Alpha-helix and AB loop and the body of the molecule, intimately related to the amyloidogenic nature"}