{"reference": "Nature. 2006 Oct 19;443(7113):870-4. Epub  2006 Oct 11", "alternative_name": "Abeta-degrading protease, Insulin protease, Insulysin & ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II & ABPP, APPI, Alzheimer disease a", "entry": "S-0103", "gene_names": "IDE & APP, A4, AD1 & APP, A4, AD1", "remarks": "Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)", "secondary_structure": "MHHHHHHAAGIPMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL#CCCCCCCCCCCCCCCCCEEEECSCCCCCTTCCCEEEEEEETTCCEEEEEECTTCSEEEEEEEESCCGGGSCTTSTTHHHHHHHHTTSCBSSCCSTTHHHHHHHHTTCEEEEEECSSCEEEEEEEEGGGHHHHHHHHHGGGTCBCCCHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHTSCTTSGGGCCCSCCHHHHTHHHHHTTCCHHHHHHHHHHHHCCGGGEEEEEEESSCHHHHHHHHHHHHTTSCCCCCCCCCCCSCSCCGGGSSEEEEECCSSSCCEEEEEEEECCCGGGTTTCHHHHHHHHHTCCSTTSHHHHHHHTTSCSCEEEEEEEEETTEEEEEEEEECCHHHHHTHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHTCCCCCHHHHHHHHHHHTTTSCGGGTTTTTTCCCCCCHHHHHHHHTTCSGGGCEEEEECGGGTTCCCEECTTTCCEEEEEECCHHHHHHHHTCCCCTTCCCCCCCTTCCCCCCCCCCCTTCCSSCEEEEECSSEEEEEEECCSCCCSEEEEEEEEECGGGTSSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTEEEEEEECSSEEEEEEEEESTTHHHHHHHHHHHHTSCCCCHHHHHHHHHHHHHHHHGGGGSCHHHHHHHHHHHHHBSSCCCHHHHHHHHTTCCHHHHHHHHHHHHHEEEEEEEEEESCCHHHHHHHHHHHHHHHHHHHCCEECCGGGCCCCCBBCCCTTEEEEEEEECSSCSSEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHTTTTCCCSEEEEEEEEETTEEEEEEEEEESSCHHHHHHHHHHHHHHHHHHHHHSCHHHHHHHHHHHHHHHHCCCSSHHHHHHHHHHHHHTTCCCTTHHHHHHHHHTTCCHHHHHHHHHHHTSTTCTTCEEEEEEEECTTCSCCCSCCCCCCCCCCCCCCCCCCCCCEECSCHHHHHHTSCBCCCCCCCCCCCCCCC&MHHHHHHAAGIPMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL#CCCCCCCCCCCCCCCTTEEEECSCCCCCTTCCCEEEEEEETTCCEEEEEECTTCSEEEEEEEESCCGGGSCTTSTTHHHHHHHHGGGCBSSSCSTTHHHHHHHHTTCEEEEEECSSCEEEEEEEEGGGHHHHHHHHHGGGTCBCCCHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHTSCTTSGGGCCCSCCHHHHTHHHHHTTCCHHHHHHHHHHHHCCGGGEEEEEEESSCHHHHHHHHHHHHTTSCCCCCCCCCCCSCSSCGGGSSEEEEECCSSSCCEEEEEEEECCCGGGTTTCHHHHHHHHHTCCSTTCHHHHHHHTTSCSCEEEEEEEEETTEEEEEEEEECCHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHTCCCCCHHHHHHHHHHHTTTSCGGGTTTTTTCCCCCCHHHHHHHHTTCSGGGCEEEEECGGGTTCCCEECTTTCCEEEEEECCHHHHHHHHTCCCCTTCCCCCCCTTCCCCCCCCCCCTTCCSSCEEEEECSSEEEEEEECSSCCCSEEEEEEEEECGGGTSSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTEEEEEEECSSEEEEEEEEESTTHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHGGGGSCHHHHHHHHHHHHHBSSCCCHHHHHHHHTTCCHHHHHHHHHHHHHEEEEEEEEEESCCHHHHHHHHHHHHHHHHHHHCCEECCGGGCCCCCBBCCCTTEEEEEEEECSSCSSEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHTTTTCCCSCEEEEEEEETTEEEEEEEEEESSCHHHHHHHHHHHHHHHHHHHHHSCHHHHHHHHHHHHHHHHCCCSSHHHHHHHHHHHHHTTCCCTTHHHHHHHHHTTCCHHHHHHHHHHHTSTTCTTCEEEEEEEECTTCSCCCSCCCCCCCCCCCSCCCCCCCCCEECCCHHHHHHTSCBCCCCCCCCCCCCCCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CBCCCCCCCCCCCCCCCEESSCCCCCCCCCCCCCCCCCCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CBCCCCCCCCCCCCCCCEESSCCCCCCCCCCCCCCCCCCC", "chain_id": "A%%B", "inchi": "InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2%%InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2", "amyloid_non_amyloid": "Non-amyloid", "pmid": "17051221", "ligand_smiles": "C1COCCO1%%C1COCCO1", "keyword": "", "peptide_protein_sequence": "chain-ID A: MHHHHHHAAGIPMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL; chain-ID B: MHHHHHHAAGIPMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL; chain-ID C: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID D: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV", "uniprot_ac": "", "protein_name": "amyloid-beta", "r_value_free": "0.223", "mutation_s_field": "No", "ligand_mw": "88.11%%88.11", "pdb_id": "2G47", "inchi_key": "RYHBNJHYFVUHQT-UHFFFAOYSA-N%%RYHBNJHYFVUHQT-UHFFFAOYSA-N", "ec_number": "3.4.24.56", "pdb_classification": "HYDROLASE", "type": "Inhibitor complex", "author": "Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.J.", "species": "", "ligand_id": "DIO%%DIO", "method": "X-RAY DIFFRACTION", "ligand_name": "1,4-DIETHYLENE DIOXIDE%%1,4-DIETHYLENE DIOXIDE", "global_stoichiometry": "Monomer - A ", "resolution": "2.1", "ligand_formula": "C4 H8 O2%%C4 H8 O2", "length": "990 ,  40 ,  40", "ligstr": "DIO:A:C4 H8 O2:88.11:1,4-DIETHYLENE DIOXIDE:C1COCCO1:InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2:RYHBNJHYFVUHQT-UHFFFAOYSA-N;DIO:B:C4 H8 O2:88.11:1,4-DIETHYLENE DIOXIDE:C1COCCO1:InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2:RYHBNJHYFVUHQT-UHFFFAOYSA-N", "description": "Crystal structure of human insulin-degrading enzyme in complex with amyloid-Beta (1-40). Insulin-degrading enzyme (IDE), a Zn2+-metalloprotease, is involved in the clearance of insulin and amyloid-Beta. Loss-of-function mutations of IDE in rodents cause glucose intolerance and cerebral accumulation of amyloid-Beta."}