{"resolution": "", "ligand_mw": "", "secondary_structure": "DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV#CCBCCCCCCCCEECCCCEESCBCCCCSCCCCCSCEESSCC", "inchi": "", "method": "SOLID-STATE NMR", "ec_number": "", "uniprot_ac": "P05067", "remarks": "40-residue beta-amyloid fibril derived from Alzheimer's disease brain", "description": "They have investigated structures of human brain-derived ABeta fibrils, using seeded fibril growth from brain extract and data from solid-state nuclear magnetic resonance and electron microscopy. Experiments on tissue from two Alzheimer's disease (AD) patients with distinct clinical histories showed a single predominant 40 residue ABeta (ABeta40) fibril structure in each patient; however, the structures were different from one another. A molecular structural model developed for ABeta40 fibrils from one patient reveals features that distinguish in-vivo- from in-vitro-produced fibrils. The data suggest that fibrils in the brain may spread from a single nucleation site, that structural variations may correlate with variations in AD, and that structure-specific amyloid imaging agents may be an important future goal.", "type": "Fibril", "ligand_smiles": "", "chain_id": "", "species": "Homo sapiens", "keyword": "Amyloid beta A4 protein", "ligstr": "", "pmid": "24034249", "mutation_s_field": "No", "author": "Lu, J.X., Qiang, W., Yau, W.M., Schwieters, C.D., Meredith, S.C., Tycko, R.", "pdb_id": "2M4J", "amyloid_non_amyloid": "Amyloid", "inchi_key": "", "ligand_name": "", "ligand_formula": "", "ligand_id": "", "r_value_free": "", "protein_name": "Amyloid-beta A4 protein", "gene_names": "APP, A4, AD1", "global_stoichiometry": "Homo 9-mer - A9 ", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "peptide_protein_sequence": "chain-ID A: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID B: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID C: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID D: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID E: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID F: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID G: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID H: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV; chain-ID I: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV", "pdb_classification": "PROTEIN FIBRIL", "reference": "Cell. 2013 Sep 12;154(6):1257-68.", "length": "40", "entry": "S-0130"}