{"resolution": "", "ligand_mw": "", "secondary_structure": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCSSCCCCCTTGGGCCCSSSCCSSBSCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEESTTCCCCCSCCCCCCCCSSCCCCCTTCCSSCCCCCTTTTCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCSCCCSSCSCCSSCCCTTCCTTCCCCCBSCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCCSCSCCSCCCCCSCSCCCCSCCCCTTCCSSCCSCSCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCTTCCCSCCCCCCCCCCCCCCSCCCCBSCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCSCCCCCCCCSSCGGGCCSSCCCCSSSCCSCCSSCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCSSSSCTTCCCCSCCSSTTCSCSSCCCCBSCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCCCCCSSCSCCSCCCCCSCCSCSCCSSSCCCSCSSCCCSCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCSCTTCSCTTCCCCSCSSCSSCCCCCSSBSCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECSSCCCCTTCCCCCCCCSCCCCCCCCCCCCCCCCSSSSCCSCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCSSCCCCCTTSCCCCTTCCCCCCCCCEEESCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCCCCCCCCSCSSCSCCSSCCCSSCCCCCCCSCCCSCSCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CTTTCCSSCSSCCSCSTTCCCSCTTCSEEESCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCCCCCSCCSSCSCCCCCCCSSCSSGGGCCCCCSSCSSCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCSSCCCCSSCTTCTTCCCSCCTTCCCSEESCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEEECCTTSCCCCCSCCCCCCCCCCCCCCSCCCCSSCSCCCSSCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCTTCCCSCCCCCCCCCCCCCSCCEESCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEEESCCCCCCCCCSCCCCCCCSSCCCCTTTCCTTSCSSCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCSCCCCCCSCSSSCSSCSSCSSCCSSSEESCCCBCCEEEEEEEEEEEEEEEEEECSCCCEEEEEESSCEEEEEEEEECSEEECTTCEEEEEEEEEECCCCCCCSCCTTSCCCCCCTTCCCCCCCCCCCCCCCSCCCCCC", "inchi": "", "method": "SOLID-STATE NMR", "ec_number": "", "uniprot_ac": "P37840", "remarks": "Atomic-resolution structure of alpha-synuclein fibrils", "description": "A high-resolution structure of an Alpha-synuclein fibril, in a form that induces robust pathology in primary neuronal culture, determined by solid-state NMR spectroscopy and validated by EM and X-ray fiber diffraction. A consensus structure with common amyloid features including parallel, in-register Beta-sheets and hydrophobic-core residues, and with substantial complexity arising from diverse structural features including an intermolecular salt bridge, a glutamine ladder, close backbone interactions involving small residues, and several steric zippers stabilizing a new orthogonal Greek-key topology. These characteristics contribute to the robust propagation of this fibril form, as supported by the structural similarity of early-onset-PD mutants.", "type": "Fibril", "ligand_smiles": "", "chain_id": "", "species": "Homo sapiens", "keyword": "Alpha-synuclein", "ligstr": "", "pmid": "27018801", "mutation_s_field": "No", "author": "Tuttle, M.D., Comellas, G., Nieuwkoop, A.J., Covell, D.J., Berthold, D.A., Kloepper, K.D., Courtney, J.M., Kim, J.K., Barclay, A.M., Kendall, A., Wan, W., Stubbs, G., Schwieters, C.D., Lee, V.M., George, J.M., Rienstra, C.M.", "pdb_id": "2N0A", "amyloid_non_amyloid": "Amyloid", "inchi_key": "", "ligand_name": "", "ligand_formula": "", "ligand_id": "", "r_value_free": "", "protein_name": "Alpha-synuclein", "gene_names": "SNCA, NACP, PARK1", "global_stoichiometry": "Homo 10-mer - A10 ", "alternative_name": "Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor", "peptide_protein_sequence": "chain-ID A: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID B: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID C: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID D: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID E: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID F: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID G: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID H: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID I: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID J: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA", "pdb_classification": "STRUCTURAL PROTEIN", "reference": "Nat Struct Mol Biol. 2016 May;23(5):409-15.", "length": "140", "entry": "S-0145"}