{"method": "SOLUTION NMR", "mutation_s_field": "No", "ec_number": "", "description": "They have solved the 3D structure of a disease-relevant ABeta(1-42) fibril polymorph, combining data from solid-state NMR spectroscopy and mass-per-length measurements from EM. The 3D structure is composed of two molecules per fibril layer, with residues 15-42 forming a double-horseshoe-like cross-Beta-sheet entity with maximally buried hydrophobic side chains. Residues 1-14 are partially ordered and in a Beta-strand conformation, but do not display unambiguous distance restraints to the remainder of the core structure.", "ligstr": "", "pmid": "27469165", "remarks": "Atomic resolution structure of a disease-relevant Abeta(1-42) amyloid fibril", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "", "species": "Homo sapiens", "secondary_structure": "DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEESSCCCSCSEEECSCSSCCSCBSSCBCCTTCCCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEECCSCCCCSEEECSCSSCCSCBSSCBCCTTCCCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEETTCSCCCSEEECSCSSCCSCBSSCBCCTTCCCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEESSCCCCCSEEECSCSSCCSCBSSCBCCTTCCCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEECCCSSCSSEEECSCSSCCSCBSSCBCCTTCCCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CEEEEESSCCSCCSEEECSCSSCCSCBSSCBCCTTCCCCEEC", "chain_id": "", "gene_names": "APP, A4, AD1", "r_value_free": "", "pdb_id": "2NAO", "reference": "Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4976-84.", "keyword": "Beta-amyloid protein 42", "protein_name": "Amyloid-beta A4 protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID B: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID C: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID D: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID E: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID F: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA", "entry": "S-0150", "length": "42", "uniprot_ac": "P05067", "author": "Walti, M.A., Ravotti, F., Arai, H., Glabe, C.G., Wall, J.S., Bockmann, A., Guntert, P., Meier, B.H., Riek, R.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 6-mer - A6 ", "inchi_key": "", "ligand_id": ""}