{"reference": "J Biol Chem. 2008 Jun 6;283(23):15853-60.", "alternative_name": "", "entry": "S-0169", "gene_names": "", "remarks": "Altered dimer interface decreases stability in an amyloidogenic kappa1 Bence Jones protein. AL-09", "secondary_structure": "ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK#CCSCCEEEESSEEEECTTCCEEEEEEESSCCTTCEEEEEECTTSCCEEEEETTTEECTTSCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCEEEEEC&ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK#CCSCCEEEECSEEEECTTCCEEEEEEESSCCTTCEEEEEECSSSCCCCCEETTTEECSSCCTTEEEECCTTEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCEEEEEC&ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK#CCSCCEEEECSEEEECTTCCEEEEEEESSCCTTCEEEEEECTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCEEEEEC&ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK#CCCCCEEEESSEEEECTTCCEEEEEEESSCCTTCEEEEEECTTSCCEEEEETTTEECTTSCTTEEEEESSSEEEEEESSCCGGGCEEEEEEECSSSSCCBCCCEEEEEC", "chain_id": "A", "inchi": "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2", "amyloid_non_amyloid": "Amyloid", "pmid": "18400753", "ligand_smiles": "[O-]S(=O)(=O)[O-]", "keyword": "Amyloidogenic immunoglobulin light chain protein AL-09", "peptide_protein_sequence": "chain-ID A: ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK; chain-ID B: ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK; chain-ID C: ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK; chain-ID D: ATDIQMTQSPSSLSASVGDRVTITCQASQDINNYLIWYQQKPGQAPKLLIYDASTLETGVPSRFSGSGSGTEFTFTISSLQPEDLATYHCQQYDNLPYTFGQGTKLEIK", "uniprot_ac": "A2NI60", "protein_name": "BRE", "r_value_free": "0.20600000", "mutation_s_field": "No", "ligand_mw": "96.06", "pdb_id": "2Q1E", "inchi_key": "QAOWNCQODCNURD-UHFFFAOYSA-L", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "type": "Protein", "author": "Baden, E.M., Owen, B.A., Peterson, F.C., Volkman, B.F., Ramirez-Alvarado, M., Thompson, J.R.", "species": "Homo sapiens", "ligand_id": "SO4", "method": "X-RAY DIFFRACTION", "ligand_name": "SULFATE ION", "global_stoichiometry": "Homo 2-mer - A2", "resolution": "2.55", "ligand_formula": "O4 S -2", "length": "109", "ligstr": "SO4:A:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L", "description": "AL-09 has an altered dimer interface that is rotated 90 degrees from the kappaI O18/O8 dimer interface. The three non-conservative mutations in AL-09 are located within the dimer interface, consistent with their role in the decreased stability of this amyloidogenic protein."}