{"method": "SOLUTION NMR", "mutation_s_field": "No", "ec_number": "", "description": "They use ?N6, a truncation variant of the naturally amyloidogenic protein Beta(2)-microglobulin (Beta(2)m), to determine the solution structure of a nonnative amyloidogenic intermediate at high resolution. The structure of ?N6 reveals a major repacking of the hydrophobic core to accommodate the nonnative peptidyl-prolyl trans-isomer at Pro32. These structural changes, together with a concomitant pH-dependent enhancement in backbone dynamics on a microsecond-millisecond timescale, give rise to a rare conformer with increased amyloidogenic potential.", "ligstr": "", "pmid": "21255727", "remarks": "Prion-like conversion during amyloid formation at atomic resolution", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "", "resolution": "", "species": "Homo sapiens", "secondary_structure": "IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM#CCCCCEEEEEESSCCCTTSCEEEEEEEESCSSSCCEEEEEETTEECSSCBCCCCCCCSSSCCCEEEBCEECCCSSCCCEEEEECTTSSSCEEEECCCCC", "chain_id": "", "gene_names": "B2M, CDABP0092, HDCMA22P", "r_value_free": "", "pdb_id": "2XKS", "reference": "Mol Cell. 2011 Jan 21;41(2):161-72.", "keyword": "BETA-2-MICROGLOBULIN", "protein_name": "Beta-2-microglobulin", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM", "entry": "S-0176", "length": "99", "uniprot_ac": "P61769", "author": "Eichner, T., Kalverda, A.P., Thompson, G.S., Homans, S.W., Radford, S.E.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "IMMUNE SYSTEM", "global_stoichiometry": "Monomer - A ", "inchi_key": "", "ligand_id": ""}