{"resolution": "1.9", "ligand_mw": "59.04%%92.09%%22.99%%92.09", "secondary_structure": "NFMLTQSHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNHVVFGGGTKLTVL#CCCEEECCCEEECTTCCEEEEEEESSSCGGGSCCEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEECTTCCEEECCCEEEEEC&NFMLTQSHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNHVVFGGGTKLTVL#CCCEEECCCEEECTTCCEEEEEEESSSCGGGSCCEEEEECTTSCEEEEEBTTTBCCTTCCTTEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEECTTCCEEECCCEEEEEC", "inchi": "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1%%InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2%%InChI=1S/Na/q+1%%InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2", "method": "X-RAY DIFFRACTION", "ec_number": "", "uniprot_ac": "", "remarks": "Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the Recombinant Variable Domain 6AJL2", "description": "They report the thermodynamic and in vitro fibrillogenic properties of several mutants of the lambda6 protein 6aJL2 in which Pro7 and/or His8 was substituted by Ser or Pro. The H8P and H8S mutants were almost as stable as the wild-type protein and were poorly fibrillogenic. In contrast, the P7S mutation decreased the thermodynamic stability of 6aJL2 and greatly enhanced its capacity to form amyloid-like fibrils in vitro. The crystal structure of the P7S mutant showed that the substitution induced both local and long-distance effects, such as the rearrangement of the V(L) (variable region of the light chain)-V(L) interface. in Space Group: P 2(1) 2(1) 2(1)", "type": "Protein", "ligand_smiles": "CC(=O)[O-]%%C(C(CO)O)O%%[Na+]%%C(C(CO)O)O", "chain_id": "A%%A%%A%%B", "species": "Homo sapiens", "keyword": "AMYLOID LAMBDA 6 LIGHT CHAIN VARIABLE REGION PIP", "ligstr": "ACT:A:C2 H3 O2 -1:59.04:ACETATE ION:CC(=O)[O-]:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1:QTBSBXVTEAMEQO-UHFFFAOYSA-M;GOL:A:C3 H8 O3:92.09:GLYCEROL:C(C(CO)O)O:InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2:PEDCQBHIVMGVHV-UHFFFAOYSA-N;nan:A:Na 1:22.99:SODIUM ION:[Na+]:InChI=1S/Na/q+1:FKNQFGJONOIPTF-UHFFFAOYSA-N;GOL:B:C3 H8 O3:92.09:GLYCEROL:C(C(CO)O)O:InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2:PEDCQBHIVMGVHV-UHFFFAOYSA-N", "pmid": "19941869", "mutation_s_field": "P7S ", "author": "Hernandez-Santoyo, A., del Pozo Yauner, L., Fuentes-Silva, D., Ortiz, E., Rudino-Pinera, E., Sanchez-Lopez, R., Horjales, E., Becerril, B., Rodriguez-Romero, A.", "pdb_id": "3B5G", "amyloid_non_amyloid": "Amyloid", "inchi_key": "QTBSBXVTEAMEQO-UHFFFAOYSA-M%%PEDCQBHIVMGVHV-UHFFFAOYSA-N%%FKNQFGJONOIPTF-UHFFFAOYSA-N%%PEDCQBHIVMGVHV-UHFFFAOYSA-N", "ligand_name": "ACETATE ION%%GLYCEROL%%SODIUM ION%%GLYCEROL", "ligand_formula": "C2 H3 O2 -1%%C3 H8 O3%%Na 1%%C3 H8 O3", "ligand_id": "ACT%%GOL%%nan%%GOL", "r_value_free": "0.21", "protein_name": "Immunoglobin lambda 6 light-chain", "gene_names": "", "global_stoichiometry": "Homo 2-mer - A2 ", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: NFMLTQSHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNHVVFGGGTKLTVL; chain-ID B: NFMLTQSHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNHVVFGGGTKLTVL", "pdb_classification": "IMMUNE SYSTEM", "reference": "J Mol Biol. 2010 Feb 19;396(2):280-92.", "length": "111", "entry": "S-0188"}