{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "A monoclonal antibody called WO2 recognises the A Beta peptide. They have determined the three-dimensional structure, to near atomic resolution, of both the antibody and the complex with its antigen, the A Beta peptide. The structures reveal the molecular basis for WO2 recognition and binding of A Beta. The A Beta peptide adopts an extended, coil-like conformation across its major immunodominant B-cell epitope between residues 2 and 8. Crystal structure of Fab wo2 bound to the n terminal domain of amyloid Beta peptide (1-16).", "ligstr": "", "pmid": "18237744", "remarks": "Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)", "amyloid_non_amyloid": "Non-amyloid", "type": "Inhibitor complex", "inchi": "", "resolution": "1.59", "species": "", "secondary_structure": "DAEFRHDSGYEVHHQK#CCBCCCCCCCCCCCCC&VTLKESGPGLLKPSQTLSLTCSFSGFSIRTSKVGVSWIRQPSGKGLEWLAHIYWDDDKRYNPSLESRLTISKDTSRDMVFMKITSVDTADTATYYCARRGFYGRKYEVNHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSESITCNVAHPASSTKVDKKIVPR#CEEEEECCSEECTTCCEEEEEEEESSCHHHHCCEEEEEEEETTSCCEEEEEECTTSCEEECTTTGGGEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEEECSTTCTTSCEEEEECCCEEEEECSCCCBCCEEEEECCCGGGGSSSEEEEEEEEEEEBSSCCEEEEGGGTBCTTEEECCCEEETTEEEEEEEEEEETTTTTTSCCEEEEEEGGGTEEEEEECCCC&DQSPQAVSSGCLLKMKLPVRLLVLMFWIPGSSSDVLMTQTPLSLPVNLGEQASISCRSSQSIVHSNGHTYLEWYLQRPGQSPKLLIYQVSTRFSGVPDRFSGSGSGTDFTLRISRVEAEDLGVYYCFQASLVPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECSEEEECTTSCEEEEEEESSCCBCTTSCBCEEEEEECTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSBSSCEECCCEEEEECCCCBCCEEEEECCCHHHHHHTEEEEEEEEEEEBSSCCEEEEEETTEEECSSEEEEECCCCTTTCCEEEEEEEEEEHHHHHHCCEEEEEEECTTCSSCEEEEEETTCC", "chain_id": "", "gene_names": "APP, A4, AD1 & Igkc, Igk-C", "r_value_free": "0.231", "pdb_id": "3BKJ", "reference": "J Mol Biol. 2008 Mar 14;377(1):181-92.", "keyword": "", "protein_name": "Amyloid-beta A4 protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: DAEFRHDSGYEVHHQK; chain-ID H: VTLKESGPGLLKPSQTLSLTCSFSGFSIRTSKVGVSWIRQPSGKGLEWLAHIYWDDDKRYNPSLESRLTISKDTSRDMVFMKITSVDTADTATYYCARRGFYGRKYEVNHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSESITCNVAHPASSTKVDKKIVPR; chain-ID L: DQSPQAVSSGCLLKMKLPVRLLVLMFWIPGSSSDVLMTQTPLSLPVNLGEQASISCRSSQSIVHSNGHTYLEWYLQRPGQSPKLLIYQVSTRFSGVPDRFSGSGSGTDFTLRISRVEAEDLGVYYCFQASLVPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "entry": "S-0191", "length": "16 ,  224 ,  252", "uniprot_ac": "", "author": "Miles, L.A., Wun, K.S., Crespi, G.A., Fodero-Tavoletti, M.T., Galatis, D., Bagley, C.J., Beyreuther, K., Masters, C.L., Cappai, R., McKinstry, W.J., Barnham, K.J., Parker, M.W.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "ligand_name": "", "pdb_classification": "IMMUNE SYSTEM", "global_stoichiometry": "Homo 2-mer -A2", "inchi_key": "", "ligand_id": ""}