{"resolution": "1.85", "ligand_mw": "35.45", "secondary_structure": "NFLVHS#CCCCCC", "inchi": "InChI=1S/ClH/h1H/p-1", "method": "X-RAY DIFFRACTION", "ec_number": "", "uniprot_ac": "P10997", "remarks": "NFLVHS segment from Islet Amyloid Polypeptide (IAPP or Amylin)", "description": "Polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of Beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct Beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains.", "type": "Fibril", "ligand_smiles": "[Cl-]", "chain_id": "A", "species": "Homo sapiens", "keyword": "Islet amyloid polypeptide", "ligstr": "CL:A:Cl -1:35.45:CHLORIDE ION:[Cl-]:InChI=1S/ClH/h1H/p-1:VEXZGXHMUGYJMC-UHFFFAOYSA-M", "pmid": "19684598", "mutation_s_field": "No", "author": "Wiltzius, J.J., Landau, M., Nelson, R., Sawaya, M.R., Apostol, M.I., Goldschmidt, L., Soriaga, A.B., Cascio, D., Rajashankar, K., Eisenberg, D.", "pdb_id": "3FR1", "amyloid_non_amyloid": "Amyloid", "inchi_key": "VEXZGXHMUGYJMC-UHFFFAOYSA-M", "ligand_name": "CHLORIDE ION", "ligand_formula": "Cl -1", "ligand_id": "CL", "r_value_free": "0.23199999", "protein_name": "Islet amyloid polypeptide", "gene_names": "", "global_stoichiometry": "Homo 2-mer - A2", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: NFLVHS", "pdb_classification": "PROTEIN FIBRIL", "reference": "Nat Struct Mol Biol. 2009 Sep;16(9):973-8.", "length": "6", "entry": "S-0231"}