{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "Polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of Beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct Beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains.", "ligstr": "", "pmid": "19684598", "remarks": "NNQNTF segment from elk prion", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "1.46", "species": "Cervus canadensis", "secondary_structure": "NNQNTF#CCCCCC", "chain_id": "", "gene_names": "", "r_value_free": "0.174", "pdb_id": "3FVA", "reference": "Nat Struct Mol Biol. 2009 Sep;16(9):973-8.", "keyword": "Major prion protein", "protein_name": "Major prion protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: NNQNTF", "entry": "S-0236", "length": "6", "uniprot_ac": "P67986", "author": "Wiltzius, J.J., Landau, M., Nelson, R., Sawaya, M.R., Apostol, M.I., Goldschmidt, L., Soriaga, A.B., Cascio, D., Rajashankar, K., Eisenberg, D.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 6-mer - A6", "inchi_key": "", "ligand_id": ""}