{"global_stoichiometry": "Monomer - A ", "ligstr": "", "uniprot_ac": "", "inchi": "", "reference": "J Neurosci. 2011 Jan 26;31(4):1419-26.", "author": "Streltsov, V.A., Varghese, J.N., Masters, C.L., Nuttall, S.D.", "type": "Inhibitor complex", "ligand_id": "", "species": "", "method": "X-RAY DIFFRACTION", "keyword": "New antigen receptor variable domain, P3(40) peptide from Amyloid beta A4 protein, New antigen receptor variable domain", "gene_names": "P05067:, APP, A4, AD1", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA#CEEEEECSEEEEETTCCEEEEEEEESCSSCCCEEEEEEEETTCCCCEECCCBTTEEEEEETTTTEEEEEECSCCGGGCEEEEEEEEEEEETTCGGGCSSEEEEEETTTEEEEEEECCCEEEEEECC&AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA#CEEEEECSEEEEETTCCEEEEEEEESCSSCCCEEEEEEEETTCCCCEECCCBTTEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEEEEEETTCCSSCCCEEEEEETTTEEEEEEECCCEEEEEECC&AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA#CEEEEECSEEEEETTCCEEEEEEEESCSSCCCEEEEEEEETTCCCEEECCCBTTEEEEEETTTTEEEEEECSCCGGGCEEEEEEEEEEEETTCCSSCCCEEEEEETTTEEEEEEECCCEEEEEECC&AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA#CEEEEECSEEEEETTCCEEEEEEEESCSSCCCEEEEEEEETTCCSCEECCCBTTEEEEEETTTTEEEEEECSCCGGGCEEEEEEEEEEEETTCCSCCCSEEEEEETTTEEEEEEECCCEEEEEECC", "amyloid_non_amyloid": "Non-amyloid", "length": "126", "remarks": "Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks", "protein_name": "Amyloid beta", "peptide_protein_sequence": "chain-ID A: AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA; chain-ID B: AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA; chain-ID C: AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA; chain-ID D: AWVDQTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQAFYVFFAEDVGSNKGAIIGLMVGGVVIGGEKGAGTALTVKAA", "ligand_name": "", "ligand_smiles": "", "pdb_id": "3MOQ", "ec_number": "", "pdb_classification": "NEUROPEPTIDE", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "0.249", "alternative_name": "P05067:, ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "description": "Crystal structure of amylogenic residues 18-41 of the A-Beta peptide presented within the CDR3 loop region of a shark Ig new antigen receptor (IgNAR) single variable domain antibody. The predominant oligomeric species is a tightly associated A-Beta dimer, with paired dimers forming a tetramer in the crystal caged within four IgNAR domains, preventing uncontrolled amyloid formation.", "resolution": "2.05", "pmid": "21273426", "entry": "S-0268"}