{"resolution": "1.92", "ligand_mw": "60.05", "secondary_structure": "GYVLGS#CEEECC&GYVLGS#CCEEEC", "inchi": "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)", "method": "X-RAY DIFFRACTION", "ec_number": "", "uniprot_ac": "P04156", "remarks": "GYVLGS segment 127-132 from human prion with V129", "description": "\"we determined crystal structures of prion segments having either Met or Val at residue 129. These 6-residue segments of PrP centered on residue 129 are \"\"steric zippers,\"\" pairs of interacting Beta-sheets. Both structures of these \"\"homozygous steric zippers\"\" reveal direct intermolecular interactions between Met or Val in one sheet and the identical residue in the mating sheet.\"", "type": "Fibril", "ligand_smiles": "CC(=O)O", "chain_id": "A", "species": "Homo sapiens", "keyword": "Major prion protein", "ligstr": "ACY:A:C2 H4 O2:60.05:ACETIC ACID:CC(=O)O:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4):QTBSBXVTEAMEQO-UHFFFAOYSA-N", "pmid": "20685658", "mutation_s_field": "V129", "author": "Apostol, M.I., Sawaya, M.R., Cascio, D., Eisenberg, D.", "pdb_id": "3NHD", "amyloid_non_amyloid": "Amyloid", "inchi_key": "QTBSBXVTEAMEQO-UHFFFAOYSA-N", "ligand_name": "ACETIC ACID", "ligand_formula": "C2 H4 O2", "ligand_id": "ACY", "r_value_free": "0.261", "protein_name": "Major prion protein", "gene_names": "", "global_stoichiometry": "Homo 12-mer - A12 ", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: GYVLGS; chain-ID B: GYVLGS", "pdb_classification": "PROTEIN FIBRIL", "reference": "J Biol Chem. 2010 Sep 24;285(39):29671-5.", "length": "6", "entry": "S-0275"}