{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "They used GGVLVN as a template for inhibitor design, which is the steric-zipper structure of the peptide segment GGVLVN from the amyloid fiber formed by 248-PAP-286, a proteolytic fragment of prostatic acid phosphatase (PAP), a protein abundant in semen. 248-PAP-286 fibers enhance HIV infection by orders of magnitude in cell culture studies, while the monomeric peptide is inactive.", "ligstr": "ACY:A:C2 H4 O2:60.05:ACETIC ACID:CC(=O)O:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4):QTBSBXVTEAMEQO-UHFFFAOYSA-N;ZN:A:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N", "pmid": "21677644", "remarks": "GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)%%InChI=1S/Zn/q+2", "resolution": "1.5", "species": "Homo sapiens", "secondary_structure": "GGVLVN#CCCCCC", "chain_id": "A%%A", "gene_names": "", "r_value_free": "0.21899999", "pdb_id": "3PPD", "reference": "Nature. 2011 Jun 15;475(7354):96-100.", "keyword": "GGVLVN peptide,  amyloid forming segment", "protein_name": "Prostatic acid phosphatase", "ligand_formula": "C2 H4 O2%%Zn 2", "peptide_protein_sequence": "chain-ID A: GGVLVN", "entry": "S-0284", "length": "6", "uniprot_ac": "P15309", "author": "Sievers, S.A., Karanicolas, J., Chang, H.W., Zhao, A., Jiang, L., Zirafi, O., Stevens, J.T., Munch, J., Baker, D., Eisenberg, D.", "ligand_smiles": "CC(=O)O%%[Zn+2]", "ligand_mw": "60.05%%65.41", "alternative_name": "", "ligand_name": "ACETIC ACID%%ZINC ION", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 6-mer - A6 ", "inchi_key": "QTBSBXVTEAMEQO-UHFFFAOYSA-N%%PTFCDOFLOPIGGS-UHFFFAOYSA-N", "ligand_id": "ACY%%ZN"}