{"resolution": "2.0", "ligand_mw": "136.99%%65.41", "secondary_structure": "GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE#CCCCCCCCCCCEEEEEEETTTTEECTTCEEEEEEECTTSCEEEEEEEECCTTSCCSCCCCTTTSCSEEEEEEECHHHHHHTTTCCCSCSCEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCC", "inchi": "InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)/p-1%%InChI=1S/Zn/q+2", "method": "X-RAY DIFFRACTION", "ec_number": "", "uniprot_ac": "P02766", "remarks": "Structure of transthyretin L55P in complex with Zn", "description": "The effect of Zn(2+) in increasing TTR L55P amyloidogenecity has been reported. Crystals of the TTR L55P-Zn(2+) complex were grown under conditions similar to those leading to higher amyloidogenic potential of the variant protein and the three-dimensional structure of the complex was determined by X-ray crystallography. Two different tetrahedral Zn(2+)-binding sites were identified: one cross-links two tetramers, while the other lies at the interface between two monomers in a dimer. The association of monomers involving the two Zn(2+)-binding sites leads to a bidimensional array with a cross-Beta structure.", "type": "Aggregating complex", "ligand_smiles": "C[As](=O)(C)[O-]%%[Zn+2]", "chain_id": "A%%A", "species": "Homo sapiens", "keyword": "Transthyretin", "ligstr": "CAC:A:C2 H6 As O2 -1:136.99:CACODYLATE ION:C[As](=O)(C)[O-]:InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)/p-1:OGGXGZAMXPVRFZ-UHFFFAOYSA-M;ZN:A:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N", "pmid": "22120741", "mutation_s_field": "L55P ", "author": "Castro-Rodrigues, A.F., Gales, L., Saraiva, M.J., Damas, A.M.", "pdb_id": "3SSG", "amyloid_non_amyloid": "Amyloid", "inchi_key": "OGGXGZAMXPVRFZ-UHFFFAOYSA-M%%PTFCDOFLOPIGGS-UHFFFAOYSA-N", "ligand_name": "CACODYLATE ION%%ZINC ION", "ligand_formula": "C2 H6 As O2 -1%%Zn 2", "ligand_id": "CAC%%ZN", "r_value_free": "0.247", "protein_name": "Transthyretin", "gene_names": "TTR, PALB", "global_stoichiometry": "Homo 4-mer - A4 ", "alternative_name": "ATTR, Prealbumin, TBPA", "peptide_protein_sequence": "chain-ID A: GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE", "pdb_classification": "HORMONE", "reference": "Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1035-44.", "length": "127", "entry": "S-0303"}