{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "The crystal structure of a fragment from human prion protein consisting of the disulfide-bond-linked portions of helices 2 and 3. Instead of forming a pair-of-sheets steric zipper structure characteristic of amyloid fibers, this fragment crystallized into a Beta-sheet-rich assembly of hexameric oligomers. This study reveals a never before observed structural motif for ordered protein aggregates and suggests a possible mechanism for self-propagation of misfolded conformations by such nonamyloid oligomers.", "ligstr": "", "pmid": "23808589", "remarks": "Fragment of human prion protein; Instead of forming a pair of sheets steric zipper reflective of amyloid, the DBPrP fragment assembled into distinct beta-sheet oligomers", "amyloid_non_amyloid": "Non-amyloid", "type": "Fibril", "inchi": "", "resolution": "2.03", "species": "", "secondary_structure": "HDCVNI#CEEEEC&EQMCIT#CEEEEC&HDCVNI#CEEEEC&EQMCIT#CEEEEC&HDCVNI#CCEEEC&EQMCIT#CEEEEC&HDCVNI#CCEEEC&EQMCIT#CEEEEC&HDCVNI#CCEEEC&EQMCIT#CEEEEC&HDCVNI#CCEEEC&EQMCIT#CEEEEC", "chain_id": "", "gene_names": "", "r_value_free": "0.253", "pdb_id": "4E1I", "reference": "J Am Chem Soc. 2013 Jul 17;135(28):10202-5.", "keyword": "", "protein_name": "Prion protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: HDCVNI; chain-ID B: EQMCIT; chain-ID C: HDCVNI; chain-ID D: EQMCIT; chain-ID E: HDCVNI; chain-ID F: EQMCIT; chain-ID G: HDCVNI; chain-ID H: EQMCIT; chain-ID I: HDCVNI; chain-ID J: EQMCIT; chain-ID K: HDCVNI; chain-ID L: EQMCIT", "entry": "S-0318", "length": "6", "uniprot_ac": "", "author": "Apostol, M.I., Perry, K., Surewicz, W.K.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "CELL CYCLE", "global_stoichiometry": "Hetero 12-mer - A6B6 ", "inchi_key": "", "ligand_id": ""}