{"global_stoichiometry": "Hetero 2-mer - AB ", "ligstr": "", "uniprot_ac": "", "inchi": "", "reference": "Sci Rep. 2013;3:1302.", "author": "Miles, L.A., Crespi, G.A., Doughty, L., Parker, M.W.", "type": "Fibril complex", "ligand_id": "", "species": "", "method": "X-RAY DIFFRACTION", "keyword": "", "gene_names": "APP, A4, AD1 & IGHG1 & IGKC", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "DAEFRHDSGYEVHHQKLVFFAEDVGSNK#CGGGCCCCCCCCCCCCCCCCCCCCCCCC&VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH#CEEEEECCCEECTTCCEEEEEEEESSCGGGSEEEEEEECTTSCEEEEEEECSSTTCEEECGGGTTTEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEEETTTTEEEEECCCEEEEECSSCCBCCEEEEECCCSCCCTTSEEEEEEEEEEEBSSCCEEEEGGGTBCTTEEECCCEECTTSCEEEEEEEEEEGGGTTTCCCEEEEEEGGGTEEEEEECCCCCCCCCCCC&EYVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC#CCCCEEEECSEEEECTTSCEEEEEEESSCCBCTTSCBCEEEEEECTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCEECCCEEEEECCCCBCCEEEEECCCHHHHHTTEEEEEEEEEEEBSSCCEEEEEETTEECCSSEEEEECCCCTTTCCEEEEEEEEEEHHHHTTCCEEEEEEECTTSSSCEEEEEESSCC", "amyloid_non_amyloid": "Amyloid", "length": "28 ,  227 ,  220", "remarks": "Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide;  targeting the amyloid (Abeta) plaques", "protein_name": "Amyloid-Beta", "peptide_protein_sequence": "chain-ID A: DAEFRHDSGYEVHHQKLVFFAEDVGSNK; chain-ID H: VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH; chain-ID L: EYVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "ligand_name": "", "ligand_smiles": "", "pdb_id": "4HIX", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL/Immune System", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "0.22", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II & Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C region KOL,", "description": "They report the crystal structure of a Fab-ABeta peptide complex that reveals Bapineuzumab captures ABeta in a monomeric helical conformation at the N-terminus. The Fab binds soluble ABeta(1-40). The structure explains the antibody's exquisite selectivity for particular ABeta species and why it cannot recognize N-terminally modified or truncated ABeta peptides.", "resolution": "2.2", "pmid": "23416764", "entry": "S-0323"}