{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "Bapineuzumab (AAB-001) and its derivative (AAB-003) are humanized versions of the anti-ABeta murine antibody 3D6 and are immunotherapy candidates in Alzheimer's disease. The common Fab fragment of these immunotherapies has been expressed, purified and crystallized in complex with Beta-amyloid peptides (residues 1-8 and 1-28).", "ligstr": "", "pmid": "24598931", "remarks": "Humanised 3D6 Fab complexed to amyloid beta 1-8", "amyloid_non_amyloid": "Non-amyloid", "type": "Inhibitor complex", "inchi": "", "resolution": "2.0", "species": "", "secondary_structure": "DAEFRHDS#CGGGTCCC&VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH#CEEEEECCCEECTTCCEEEEEEEESSCGGGSCEEEEEECTTSCEEEEEEECSSTTCEEECTTTTTTEEEEEEGGGTEEEEEECSCCGGGCEEEEEEEEETTTTEEEEECCCEEEEECSSCCBCCEEEEECCCSSCCTTSCEEEEEEEEEEBSSCCEEEEGGGTCCTTEEECCCEECTTSCEEEEEEEEECGGGBTTBCCEEEEEEGGGTEEEEEECCCCCCCCCCCC&YVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC#CCCEEEECSEEEECTTSCEEEEEEESSCCBCTTSCBCEEEEEECTTSCCEEEEETTTEECTTCCTTEEEEEETTEEEEEESSCCGGGCEEEEEEECSSSSCEECCCEEEEECCCCBCCEEEEECCCTTGGGTTEEEEEEEEEEEBSSCCEEEEEESSCBCCSSEEEEECCCCTTTCCEEEEEEEEEETTTTTSCCCEEEEEECTTSSSCEEEEECSSCC", "chain_id": "", "gene_names": "APP, A4, AD1", "r_value_free": "0.215", "pdb_id": "4OJF", "reference": "Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):374-7.", "keyword": "", "protein_name": "Amyloid-Beta", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: DAEFRHDS; chain-ID H: VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH; chain-ID L: YVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "entry": "S-0355", "length": "8 ,  227 ,  219", "uniprot_ac": "", "author": "Crespi, G.A.N., Ascher, D.B., Parker, M.W., Miles, L.A.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "ligand_name": "", "pdb_classification": "IMMUNE SYSTEM", "global_stoichiometry": "Hetero 2-mer - AB ", "inchi_key": "", "ligand_id": ""}