{"reference": "Nature. 2015 Sep 24;525(7570):486-90.", "alternative_name": "", "entry": "S-0385", "gene_names": "", "remarks": "Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77", "secondary_structure": "AVVTGVTAV#CCCCCCCCC", "chain_id": "", "inchi": "", "amyloid_non_amyloid": "Amyloid", "pmid": "26352473", "ligand_smiles": "", "keyword": "Alpha-synuclein", "peptide_protein_sequence": "chain-ID A: AVVTGVTAV", "uniprot_ac": "P37840", "protein_name": "Alpha-synuclein", "r_value_free": "0.221", "mutation_s_field": "No", "ligand_mw": "", "pdb_id": "4RIK", "inchi_key": "", "ec_number": "", "pdb_classification": "LIPID BINDING PROTEIN", "type": "Fibril", "author": "Rodriguez, J.A., Ivanova, M.I., Sawaya, M.R., Cascio, D., Reyes, F.E., Shi, D., Sangwan, S., Guenther, E.L., Johnson, L.M., Zhang, M., Jiang, L., Arbing, M.A., Nannenga, B.L., Hattne, J., Whitelegge, J., Brewster, A.S., Messerschmidt, M., Boutet, S., Saut", "species": "Homo sapiens", "ligand_id": "", "method": "X-RAY DIFFRACTION", "ligand_name": "", "global_stoichiometry": "Homo 10-mer - A10 ", "resolution": "1.85", "ligand_formula": "", "length": "9", "ligstr": "", "description": "An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxicity of human Alpha-synuclein. The structure exhibits protofibrils built of pairs of face-to-face Beta-sheets. X-ray fibre diffraction patterns show the similarity of NACore to toxic fibrils of full-length Alpha-synuclein. The NACore structure, together with that of a second segment, inspires a model for most of the ordered portion of the toxic, full-length Alpha-synuclein fibril, presenting opportunities for the design of inhibitors of Alpha-synuclein fibrils. "}