{"method": "ELECTRON CRYSTALLOGRAPHY", "pmid": "26352473", "pdb_classification": "LIPID BINDING PROTEIN", "ec_number": "", "uniprot_ac": "P37840", "protein_name": "Alpha-synuclein", "chain_id": "", "ligand_id": "", "description": "An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxicity of human Alpha-synuclein. The structure exhibits protofibrils built of pairs of face-to-face Beta-sheets. X-ray fibre diffraction patterns show the similarity of NACore to toxic fibrils of full-length Alpha-synuclein. The NACore structure, together with that of a second segment, inspires a model for most of the ordered portion of the toxic, full-length Alpha-synuclein fibril, presenting opportunities for the design of inhibitors of Alpha-synuclein fibrils. ", "entry": "S-0386", "pdb_id": "4RIL", "global_stoichiometry": "Homo 10-mer - A10 ", "ligand_name": "", "gene_names": "", "inchi_key": "", "ligstr": "", "reference": "Nature. 2015 Sep 24;525(7570):486-90.", "inchi": "", "ligand_smiles": "", "ligand_formula": "", "resolution": "1.43", "author": "Rodriguez, J.A., Ivanova, M.I., Sawaya, M.R., Cascio, D., Reyes, F.E., Shi, D., Sangwan, S., Guenther, E.L., Johnson, L.M., Zhang, M., Jiang, L., Arbing, M.A., Nannenga, B.L., Hattne, J., Whitelegge, J., Brewster, A.S., Messerschmidt, M., Boutet, S., Saut", "species": "Homo sapiens", "amyloid_non_amyloid": "Amyloid", "secondary_structure": "GAVVTGVTAVA#CCCCCCCCCCC", "remarks": "Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction", "mutation_s_field": "No", "length": "11", "keyword": "Alpha-synuclein", "ligand_mw": "", "type": "Fibril", "r_value_free": "0.275", "alternative_name": "", "peptide_protein_sequence": "chain-ID A: GAVVTGVTAVA"}