{"reference": "Cancer Cell. 2016 Jan 11;29(1):90-103.", "alternative_name": "", "entry": "S-0388", "gene_names": "", "remarks": "Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)", "secondary_structure": "TIITLE#CCCCCC", "chain_id": "Z", "inchi": "InChI=1S/Zn/q+2", "amyloid_non_amyloid": "Amyloid", "pmid": "26748848", "ligand_smiles": "[Zn+2]", "keyword": "TIITLE hexapeptide segment from p53", "peptide_protein_sequence": "chain-ID Z: TIITLE", "uniprot_ac": "P04637", "protein_name": "Cellular tumor antigen p53", "r_value_free": "0.192", "mutation_s_field": "No", "ligand_mw": "65.41", "pdb_id": "4RP7", "inchi_key": "PTFCDOFLOPIGGS-UHFFFAOYSA-N", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "type": "Fibril", "author": "Soragni, A., Janzen, D.M., Johnson, L.M., Lindgren, A.G., Thai-Quynh Nguyen, A., Tiourin, E., Soriaga, A.B., Lu, J., Jiang, L., Faull, K.F., Pellegrini, M., Memarzadeh, S., Eisenberg, D.S.", "species": "Homo sapiens", "ligand_id": "ZN", "method": "X-RAY DIFFRACTION", "ligand_name": "ZINC ION", "global_stoichiometry": "Homo 6-mer - A6", "resolution": "1.58", "ligand_formula": "Zn 2", "length": "6", "ligstr": "ZN:Z:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N", "description": "They show that a cell-penetrating peptide, ReACp53, designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC), an aggressive cancer characterized by ubiquitous p53 mutations. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death."}