{"resolution": "1.8", "ligand_mw": "", "secondary_structure": "KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH#CCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSCCSCCCCTTTCCSEEEEEEECHHHHHHHTTCCCSEEEEEEEEEECCSSSCEEEEEEEEETTEEEEEEEEECCCCCCCCCC&KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH#CCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSCCSCCCCTTTCCSEEEEEEECHHHHHHHTTCCCSBSCEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCCCCCCCC", "inchi": "", "method": "X-RAY DIFFRACTION", "ec_number": "", "uniprot_ac": "P02766", "remarks": "Crystal Structure of Human Transthyretin Leu55Pro Mutant", "description": "They identify Beta-strands F and H as necessary for TTR aggregation. Based on the crystal structures of these segments, they designed two non-natural peptide inhibitors that block aggregation. This work provides the first characterization of peptide inhibitors for TTR aggregation, establishing a novel therapeutic strategy.", "type": "Protein", "ligand_smiles": "", "chain_id": "", "species": "Homo sapiens", "keyword": "Transthyretin", "ligstr": "", "pmid": "26459562", "mutation_s_field": "L55P", "author": "Saelices, L., Johnson, L.M., Liang, W.Y., Sawaya, M.R., Cascio, D., Ruchala, P., Whitelegge, J., Jiang, L., Riek, R., Eisenberg, D.S.", "pdb_id": "4TKW", "amyloid_non_amyloid": "Amyloid", "inchi_key": "", "ligand_name": "", "ligand_formula": "", "ligand_id": "", "r_value_free": "0.2", "protein_name": "Transthyretin", "gene_names": "TTR, PALB", "global_stoichiometry": "Homo 4-mer - A4 ", "alternative_name": "ATTR, Prealbumin, TBPA", "peptide_protein_sequence": "chain-ID A: KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH; chain-ID B: KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH", "pdb_classification": "TRANSPORT PROTEIN", "reference": "J Biol Chem. 2015 Nov 27;290(48):28932-43.", "length": "125", "entry": "S-0389"}