{"reference": "J Biol Chem. 2015 Nov 27;290(48):28932-43.", "alternative_name": "ATTR, Prealbumin, TBPA", "entry": "S-0394", "gene_names": "TTR, PALB", "remarks": "Crystal structure of human transthyretin", "secondary_structure": "KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH#CCCEEEEEEETTTTEECTTCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSEEEEEEEEEESTTSCCEEEEEEEEETTEEEEEEEEECCCCCCCCCC&KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH#CCCEEEEEEETTTTEECCSCEEEEEEECTTSCEEEEEEEECCTTSEECCSCCTTTCCSEEEEEEECHHHHHHHTTCCCSEEEEEEEEEECCSSSCEEEEEEEEETTEEEEEEEEECCCCCCCCCC", "chain_id": "A%%A%%B%%B", "inchi": "InChI=1S/Mg/q+2%%InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1%%InChI=1S/Mg/q+2%%InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1", "amyloid_non_amyloid": "Amyloid", "pmid": "26459562", "ligand_smiles": "[Mg+2]%%C([C@@H](C(=O)O)N)S(=O)(=O)O%%[Mg+2]%%C([C@@H](C(=O)O)N)S(=O)(=O)O", "keyword": "Transthyretin", "peptide_protein_sequence": "chain-ID A: KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH; chain-ID B: KCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH", "uniprot_ac": "P02766", "protein_name": "Transthyretin", "r_value_free": "0.23199999", "mutation_s_field": "No", "ligand_mw": "24.31%%169.16%%24.31%%169.16", "pdb_id": "4TLT", "inchi_key": "JLVVSXFLKOJNIY-UHFFFAOYSA-N%%XVOYSCVBGLVSOL-REOHCLBHSA-N%%JLVVSXFLKOJNIY-UHFFFAOYSA-N%%XVOYSCVBGLVSOL-REOHCLBHSA-N", "ec_number": "", "pdb_classification": "TRANSPORT PROTEIN", "type": "Protein", "author": "Saelices, L., Johnson, L.M., Liang, W.Y., Sawaya, M.R., Cascio, D., Ruchala, P., Whitelegge, J., Jiang, L., Riek, R., Eisenberg, D.S.", "species": "Homo sapiens", "ligand_id": "MG%%OCS%%MG%%OCS", "method": "X-RAY DIFFRACTION", "ligand_name": "MAGNESIUM ION%%CYSTEINESULFONIC ACID%%MAGNESIUM ION%%CYSTEINESULFONIC ACID", "global_stoichiometry": "Homo 4-mer - A4 ", "resolution": "1.7", "ligand_formula": "Mg 2%%C3 H7 N O5 S%%Mg 2%%C3 H7 N O5 S", "length": "125", "ligstr": "MG:A:Mg 2:24.31:MAGNESIUM ION:[Mg+2]:InChI=1S/Mg/q+2:JLVVSXFLKOJNIY-UHFFFAOYSA-N;OCS:A:C3 H7 N O5 S:169.16:CYSTEINESULFONIC ACID:C([C@@H](C(=O)O)N)S(=O)(=O)O:InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1:XVOYSCVBGLVSOL-REOHCLBHSA-N;MG:B:Mg 2:24.31:MAGNESIUM ION:[Mg+2]:InChI=1S/Mg/q+2:JLVVSXFLKOJNIY-UHFFFAOYSA-N;OCS:B:C3 H7 N O5 S:169.16:CYSTEINESULFONIC ACID:C([C@@H](C(=O)O)N)S(=O)(=O)O:InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1:XVOYSCVBGLVSOL-REOHCLBHSA-N", "description": "They identify Beta-strands F and H as necessary for TTR aggregation. Based on the crystal structures of these segments, they designed two non-natural peptide inhibitors that block aggregation. This work provides the first characterization of peptide inhibitors for TTR aggregation, establishing a novel therapeutic strategy."}