{"method": "X-RAY DIFFRACTION", "mutation_s_field": "Y38E/F99A/F101E", "ec_number": "", "description": "They identify the monomeric form of the Mcg immunoglobulin light chain variable domain as the quaternary unit required for amyloid fiber assembly. Dimers of Mcg variable domains remain stable and soluble, yet become prone to assemble into amyloid fibers upon disassociation into monomers. ", "ligstr": "SO4:A:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L;SO4:C:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L;SO4:D:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L;SO4:E:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L;SO4:F:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L;SO4:H:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L", "pmid": "25138218", "remarks": "Induced monomer of the Mcg variable domain; Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains.", "amyloid_non_amyloid": "Amyloid", "type": "Protein", "inchi": "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2%%InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2%%InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2%%InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2%%InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2%%InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2", "resolution": "2.7", "species": "Homo sapiens", "secondary_structure": "GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCEEBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEECCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCEEEEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEECCCCCEEEBCCEEEEEC&GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL#CCCCBBCCSEEEECTTSCCCCEEECCTTTTTTCSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTSCCEEETTEEECCCCCCCCCCCEEEEEEEECCCCCEEEBCCEEEEEC", "chain_id": "A%%C%%D%%E%%F%%H", "gene_names": "IGLV2-8", "r_value_free": "0.289", "pdb_id": "4UNT", "reference": "J Biol Chem. 2014 Oct 3;289(40):27513-25.", "keyword": "IG LAMBDA CHAIN V-II REGION MGC", "protein_name": "Immunoglobulin lambda variable 2-8", "ligand_formula": "O4 S -2%%O4 S -2%%O4 S -2%%O4 S -2%%O4 S -2%%O4 S -2", "peptide_protein_sequence": "chain-ID A: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID B: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID C: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID D: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID E: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID F: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID G: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL; chain-ID H: GQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWEQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNAVEGTGTKVTVL", "entry": "S-0402", "length": "111", "uniprot_ac": "P01709", "author": "Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S.", "ligand_smiles": "[O-]S(=O)(=O)[O-]%%[O-]S(=O)(=O)[O-]%%[O-]S(=O)(=O)[O-]%%[O-]S(=O)(=O)[O-]%%[O-]S(=O)(=O)[O-]%%[O-]S(=O)(=O)[O-]", "ligand_mw": "96.06%%96.06%%96.06%%96.06%%96.06%%96.06", "alternative_name": "Ig lambda chain V-II region BO, Ig lambda chain V-II region MGC", "ligand_name": "SULFATE ION%%SULFATE ION%%SULFATE ION%%SULFATE ION%%SULFATE ION%%SULFATE ION", "pdb_classification": "IMMUNE SYSTEM", "global_stoichiometry": "Homo 8-mer - A8", "inchi_key": "QAOWNCQODCNURD-UHFFFAOYSA-L%%QAOWNCQODCNURD-UHFFFAOYSA-L%%QAOWNCQODCNURD-UHFFFAOYSA-L%%QAOWNCQODCNURD-UHFFFAOYSA-L%%QAOWNCQODCNURD-UHFFFAOYSA-L%%QAOWNCQODCNURD-UHFFFAOYSA-L", "ligand_id": "SO4%%SO4%%SO4%%SO4%%SO4%%SO4"}