{"method": "ELECTRON CRYSTALLOGRAPHY", "mutation_s_field": "No", "ec_number": "", "description": "An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxicity of human Alpha-synuclein. The structure exhibits protofibrils built of pairs of face-to-face Beta-sheets. X-ray fibre diffraction patterns show the similarity of NACore to toxic fibrils of full-length Alpha-synuclein. The NACore structure, together with that of a second segment, inspires a model for most of the ordered portion of the toxic, full-length Alpha-synuclein fibril, presenting opportunities for the design of inhibitors of Alpha-synuclein fibrils. ", "ligstr": "", "pmid": "26352473", "remarks": "MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "1.41", "species": "Homo sapiens", "secondary_structure": "GVVHGVTTVA#CCCCCCCCCC", "chain_id": "", "gene_names": "", "r_value_free": "0.282", "pdb_id": "4ZNN", "reference": "Nature. 2015 Sep 24;525(7570):486-90.", "keyword": "Alpha-synuclein", "protein_name": "Alpha-synuclein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: GVVHGVTTVA", "entry": "S-0408", "length": "10", "uniprot_ac": "P37840", "author": "Rodriguez, J.A., Ivanova, M.I., Sawaya, M.R., Cascio, D., Reyes, F.E., Shi, D., Sangwan, S., Guenther, E.L., Johnson, L.M., Zhang, M., Jiang, L., Arbing, M.A., Nannenga, B.L., Hattne, J., Whitelegge, J., Brewster, A.S., Messerschmidt, M., Boutet, S., Saut", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "LIPID BINDING PROTEIN", "global_stoichiometry": "Homo 10-mer - A10 ", "inchi_key": "", "ligand_id": ""}