{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "They determined four new crystal structures of segments within IAPP, all forming steric zippers. One of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. These results provide additional evidence of out-of-register Beta sheets as a common structural motif in amyloid aggregates.", "ligstr": "", "pmid": "26629790", "remarks": "Structure of amyloid forming peptide NFGAILS (residues 22-28) from Islet Amyloid Polypeptide", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "1.24", "species": "Homo sapiens", "secondary_structure": "NFGAILS#CCEEEEC&NFGAILS#CCEEEEC", "chain_id": "", "gene_names": "", "r_value_free": "0.20600000", "pdb_id": "5E5V", "reference": "J Phys Chem B. 2016 Jul 7;120(26):5810-6.", "keyword": "NFGAILS (22-28) from islet amyloid polypeptide,  synthesized", "protein_name": "Islet Amyloid Polypeptide", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: NFGAILS; chain-ID B: NFGAILS", "entry": "S-0424", "length": "7", "uniprot_ac": "", "author": "Soriaga, A.B., Sangwan, S., Macdonald, R., Sawaya, M.R., Eisenberg, D.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "de novo protein", "global_stoichiometry": "Homo 12-mer - A12", "inchi_key": "", "ligand_id": ""}