{"global_stoichiometry": "Homo 10-mer - A10", "ligstr": "", "uniprot_ac": "", "inchi": "", "reference": "J Phys Chem B. 2016 Jul 7;120(26):5810-6.", "author": "Soriaga, A.B., Sangwan, S., Macdonald, R., Sawaya, M.R., Eisenberg, D.", "type": "Fibril", "ligand_id": "", "species": "Homo sapiens", "method": "X-RAY DIFFRACTION", "keyword": "ANFLVH (residues 13-18) from islet amyloid polypeptide", "gene_names": "", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "ANFLVH#CCCCCC", "amyloid_non_amyloid": "Amyloid", "length": "6", "remarks": "Structure of the amyloid forming peptide ANFLVH (residues 13-18) from islet amyloid polypeptide", "protein_name": "Islet Amyloid Polypeptide", "peptide_protein_sequence": "chain-ID A: ANFLVH", "ligand_name": "", "ligand_smiles": "", "pdb_id": "5E5X", "ec_number": "", "pdb_classification": "de novo protein", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "0.161", "alternative_name": "", "description": "They determined four new crystal structures of segments within IAPP, all forming steric zippers. One of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. These results provide additional evidence of out-of-register Beta sheets as a common structural motif in amyloid aggregates.", "resolution": "1.61", "pmid": "26629790", "entry": "S-0425"}