{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "1.15.1.1", "description": "They determine the corkscrew-like structure of a cytotoxic segment of superoxide dismutase 1 (SOD1) in its oligomeric state. Residues 28\u00e2\u20ac\u201c38 of SOD1 (with the sequence PVKVWGSIKGL) have the potential to form a toxic amyloid oligomers. To increase solubility for crystallization, they engineered a single-residue substitution: P28K. The crystal structure shows a twisted Beta-sheet built of antiparallel, out-of-register Beta-strands. Describing its shape, they term it the \u00e2\u20ac\u0153corkscrew\u00e2\u20ac\u009d.", "ligstr": "", "pmid": "28760994", "remarks": "Corkscrew assembly of SOD1 residues 28-38 without potassium iodide", "amyloid_non_amyloid": "Non-amyloid", "type": "Peptide", "inchi": "", "resolution": "2.0", "species": "Homo sapiens", "secondary_structure": "KVKVWGSIKGL#CEEEEECCTTC&KVKVWGSIKGL#CEEEEEECTTC&KVKVWGSIKGL#CEEEEEEETTC&KVKVWGSIKGL#CEEEEEECTTC&KVKVWGSIKGL#CEEEEEEETTC&KVKVWGSIKGL#CEEEEEECTTC&KVKVWGSIKGL#CEEEEEECTTC&KVKVWGSIKGL#CEEEEECCTTC", "chain_id": "", "gene_names": "", "r_value_free": "0.252", "pdb_id": "5IIW", "reference": "Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775.", "keyword": "Superoxide dismutase [Cu-Zn]", "protein_name": "Superoxide dismutase [Cu-Zn]", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: KVKVWGSIKGL; chain-ID B: KVKVWGSIKGL; chain-ID C: KVKVWGSIKGL; chain-ID D: KVKVWGSIKGL; chain-ID E: KVKVWGSIKGL; chain-ID F: KVKVWGSIKGL; chain-ID G: KVKVWGSIKGL; chain-ID H: KVKVWGSIKGL", "entry": "S-0430", "length": "11", "uniprot_ac": "P00441", "author": "Sangwan, S., Zhao, A., Adams, K.L., Jayson, C.K., Sawaya, M.R., Guenther, E.L., Pan, A.C., Ngo, J., Moore, D.M., Soriaga, A.B., Do, T.D., Goldschmidt, L., Nelson, R., Bowers, M.T., Koehler, C.M., Shaw, D.E., Novitch, B.G., Eisenberg, D.S.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "UNKNOWN FUNCTION", "global_stoichiometry": "Homo 8-mer - A8 ", "inchi_key": "", "ligand_id": ""}