{"reference": "Sci Rep. 2017 Dec 1;7(1):16809.", "alternative_name": "", "entry": "S-0451", "gene_names": "", "remarks": "Crystal structure of non-amyloidogenic light chain dimer M7", "secondary_structure": "SSELTQDPAVSVALGQTVKITCQGDSLRMYYASWYQQKPAQAPVLVIYAEKNRPSGIPDRFSASSSGSTASLTITGAQAEDEADYYCNSRDNSGDHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS#CCCCCCCCCCEEETTCCEEEECCSTTTTTCCCCCEEECTTSCCBCCCCCSSCCCCSSCCCCCCCCCCCCCEEEESSCCGGGCEEEECCCCCCCCCCCCCCCCEEEEEESSCCBCCEEEEECCCHHHHHTTCEEEEEEEEEEBSSCCEEEEEETTEEECTTEEECCCEECTTSCEEEEEEEEECHHHHHHSSCEEEEEEETTEEEEEEECCCCCC&SSELTQDPAVSVALGQTVKITCQGDSLRMYYASWYQQKPAQAPVLVIYAEKNRPSGIPDRFSASSSGSTASLTITGAQAEDEADYYCNSRDNSGDHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS#CCCCBCCSEEEEETTSCEEEEEECGGGGTSCCEEEEECTTSCCEEEEBTTTBCCTTSCTTEEEEEETTEEEEEESSCCGGGCSEEEEEEECSSSSCEEECCCEEEEEESCCCBCCEEEEECCCHHHHHTTCCCEEEEEEEEBSSCCEEEEEETTEEECTTEEECCCEECTTSCEEEEEEECCCHHHHHHSSCEEEEEEETTEEEEEEECCCCCC", "chain_id": "A", "inchi": "InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2", "amyloid_non_amyloid": "Non-amyloid", "pmid": "29196671", "ligand_smiles": "C(C(CO)O)O", "keyword": "light chain dimer", "peptide_protein_sequence": "chain-ID A: SSELTQDPAVSVALGQTVKITCQGDSLRMYYASWYQQKPAQAPVLVIYAEKNRPSGIPDRFSASSSGSTASLTITGAQAEDEADYYCNSRDNSGDHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS; chain-ID B: SSELTQDPAVSVALGQTVKITCQGDSLRMYYASWYQQKPAQAPVLVIYAEKNRPSGIPDRFSASSSGSTASLTITGAQAEDEADYYCNSRDNSGDHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "uniprot_ac": "", "protein_name": "Immunoglobin light chain dimer M7", "r_value_free": "0.239", "mutation_s_field": "No", "ligand_mw": "92.09", "pdb_id": "5MVG", "inchi_key": "PEDCQBHIVMGVHV-UHFFFAOYSA-N", "ec_number": "", "pdb_classification": "IMMUNE SYSTEM", "type": "Protein", "author": "Oberti, L., Rognoni, P., Barbiroli, A., Lavatelli, F., Russo, R., Maritan, M., Palladini, G., Bolognesi, M., Merlini, G., Ricagno, S.", "species": "Homo sapiens", "ligand_id": "GOL", "method": "X-RAY DIFFRACTION", "ligand_name": "GLYCEROL", "global_stoichiometry": "Homo 2-mer - A2 ", "resolution": "2.2", "ligand_formula": "C3 H8 O3", "length": "214", "ligstr": "GOL:A:C3 H8 O3:92.09:GLYCEROL:C(C(CO)O)O:InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2:PEDCQBHIVMGVHV-UHFFFAOYSA-N", "description": "Eight amyloidogenic LCs were selected as responsible for severe cardiac symptoms in patients; five non-amyloidogenic LCs were isolated from patients affected by multiple myeloma. They showed that low fold stability and high protein dynamics correlate with amyloidogenic LCs, while hydrophobicity, structural rearrangements and nature of the LC dimeric association interface do not appear to play a significant role in defining amyloid propensity."}