{"global_stoichiometry": "Homo 10-mer - A10", "ligstr": "", "uniprot_ac": "P10636", "inchi": "", "reference": "Nature. 2017 Jul 13;547(7662):185-190.", "author": "Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.J., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.", "type": "Fibril", "ligand_id": "", "species": "Homo sapiens", "method": "ELECTRON MICROSCOPY", "keyword": "Microtubule-associated protein tau", "gene_names": "MAPT, MAPTL, MTBT1, TAU", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CBCCBCCBCCCCEECCBSCCCCEECCCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CEEEECCBCCCCEECCBSCCCCEEECCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CBCCBCCBCCCCEECCBSCCCCEECCCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CEEEECCBCCCCEECCBSCCCCEEECCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CBCCBCCBCCCCEECCBSCCCCEECCCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CEEEECCBCCCCEECCBSCCCCEEECCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CBCCBCCBCCCCEECCBSCCCCEECCCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CEEEECCBCCCCEECCBSCCCCEEECCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CBCCBCCBCCCCEECCBSCCCCEECCCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC&VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF#CEEEECCBCCCCEECCBSCCCCEEECCCCCCEEEECSCCCCCSSCBCCBSCCEECCBCCSSCCCBCCCCCCCC", "amyloid_non_amyloid": "Amyloid", "length": "73", "remarks": "Straight filament in Alzheimer's disease brain", "protein_name": "Microtubule-associated protein tau", "peptide_protein_sequence": "chain-ID A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID B: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID C: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID D: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID E: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID F: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID G: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID H: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID I: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF; chain-ID J: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF", "ligand_name": "", "ligand_smiles": "", "pdb_id": "5O3T", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "", "alternative_name": "Neurofibrillary tangle protein, Paired helical filament-tau", "description": "They present cryo-electron microscopy (cryo-EM) maps corresponding atomic models of paired helical and straight filaments from the brain of an individual with Alzheimer's disease. Filament cores are made of two identical protofilaments comprising residues 306-378 of tau protein, which adopt a combined cross-Beta/Beta-helix structure and define the seed for tau aggregation. Paired helical and straight filaments differ in their inter-protofilament packing, showing that they are ultrastructural polymorphs.", "resolution": "3.4", "pmid": "28678775", "entry": "S-0458"}