{"method": "ELECTRON MICROSCOPY", "mutation_s_field": "No", "ec_number": "", "description": "\"They present the structure of an ABeta(1-42) fibril composed of two intertwined protofilaments determined by cryo-electron microscopy. The backbone of all 42 residues and nearly all side chains are well resolved, including the entire N terminus, which is part of the cross-Beta structure resulting in an overall \"\"LS\"\"-shaped topology of individual subunits. The dimer interface protects the hydrophobic C termini from the solvent. The characteristic staggering of the nonplanar subunits results in markedly different fibril ends, termed \"\"groove\"\" and \"\"ridge,\"\" leading to different binding pathways on both fibril ends, which has implications for fibril growth.\"", "ligstr": "", "pmid": "28882996", "remarks": "Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "4.0", "species": "Homo sapiens", "secondary_structure": "DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC&DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA#CCEEEEEEEEEEEEEEEEEEEESCSCCEEEEEEEECSCCEEC", "chain_id": "", "gene_names": "APP, A4, AD1", "r_value_free": "", "pdb_id": "5OQV", "reference": "Science. 2017 Oct 6;358(6359):116-119.", "keyword": "Amyloid beta A4 protein", "protein_name": "Amyloid-beta A4 protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID B: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID C: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID D: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID E: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID F: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID G: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID H: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; chain-ID I: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA", "entry": "S-0462", "length": "42", "uniprot_ac": "P05067", "author": "Gremer, L., Scholzel, D., Schenk, C., Reinartz, E., Labahn, J., Ravelli, R.B.G., Tusche, M., Lopez-Iglesias, C., Hoyer, W., Heise, H., Willbold, D., Schroder, G.F.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "ABPP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta precursor protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 9-mer - A9 ", "inchi_key": "", "ligand_id": ""}