{"reference": "Biochemistry. 2017 Feb 7;56(5):757-766.", "alternative_name": "", "entry": "S-0463", "gene_names": "", "remarks": "Immunoglobulin light chain variable domain AL-T05", "secondary_structure": "QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL#CCSBBCCSEEEECTTCCEEEEEECCIIIIITSCCEEEEECTTSCCEEEEBTTTBCCTBCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEEETTTTEEEEBCCEEEEEC&QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL#CCSBBCCSEEEECTTCCEEEEEECCTTTTTTSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCTBTCEEEEEEEEETTTTEEEEBCCEEEEEC&QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL#CCSBBCCSEEEECTTSCEEEEEECCTTTTTTSCEEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEEETTTTEEEEBCCEEEEEC&QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL#CCSBBCCSEEEECTTCCEEEEEECCIIIIITSCCEEEEECTTSCCEEEEBTTTBCCTTCCTTEEEEEETTEEEEEECSCCGGGCEEEEEEEEETTTTEEEEBCCEEEEEC", "chain_id": "A%%A%%B%%B%%C%%C%%D%%D", "inchi": "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1%%InChI=1S/Zn/q+2%%InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1%%InChI=1S/Zn/q+2%%InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1%%InChI=1S/Zn/q+2%%InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1%%InChI=1S/Zn/q+2", "amyloid_non_amyloid": "Amyloid", "pmid": "28074646", "ligand_smiles": "CC(=O)[O-]%%[Zn+2]%%CC(=O)[O-]%%[Zn+2]%%CC(=O)[O-]%%[Zn+2]%%CC(=O)[O-]%%[Zn+2]", "keyword": "ALT-05 immunoglobulin light chain variable domain from light chain amyloidosis patient", "peptide_protein_sequence": "chain-ID A: QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL; chain-ID B: QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL; chain-ID C: QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL; chain-ID D: QSVLTQPPSVSAAPGQTVTISCSGSSSNIGNNYVSWYQHLPGTAPKFLIYDNNKRPSGIPDRFSGFKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVL", "uniprot_ac": "", "protein_name": "Immunoglobulin light chain variable domain AL-T05", "r_value_free": "0.223", "mutation_s_field": "No", "ligand_mw": "59.04%%65.41%%59.04%%65.41%%59.04%%65.41%%59.04%%65.41", "pdb_id": "5T93", "inchi_key": "QTBSBXVTEAMEQO-UHFFFAOYSA-M%%PTFCDOFLOPIGGS-UHFFFAOYSA-N%%QTBSBXVTEAMEQO-UHFFFAOYSA-M%%PTFCDOFLOPIGGS-UHFFFAOYSA-N%%QTBSBXVTEAMEQO-UHFFFAOYSA-M%%PTFCDOFLOPIGGS-UHFFFAOYSA-N%%QTBSBXVTEAMEQO-UHFFFAOYSA-M%%PTFCDOFLOPIGGS-UHFFFAOYSA-N", "ec_number": "", "pdb_classification": "IMMUNE SYSTEM", "type": "Protein", "author": "Blancas-Mejia, L.M., Misra, P., Ramirez-Alvarado, M.", "species": "Homo sapiens", "ligand_id": "ACT%%ZN%%ACT%%ZN%%ACT%%ZN%%ACT%%ZN", "method": "X-RAY DIFFRACTION", "ligand_name": "ACETATE ION%%ZINC ION%%ACETATE ION%%ZINC ION%%ACETATE ION%%ZINC ION%%ACETATE ION%%ZINC ION", "global_stoichiometry": "Homo 2-mer -A2", "resolution": "1.9", "ligand_formula": "C2 H3 O2 -1%%Zn 2%%C2 H3 O2 -1%%Zn 2%%C2 H3 O2 -1%%Zn 2%%C2 H3 O2 -1%%Zn 2", "length": "110", "ligstr": "ACT:A:C2 H3 O2 -1:59.04:ACETATE ION:CC(=O)[O-]:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1:QTBSBXVTEAMEQO-UHFFFAOYSA-M;ZN:A:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N;ACT:B:C2 H3 O2 -1:59.04:ACETATE ION:CC(=O)[O-]:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1:QTBSBXVTEAMEQO-UHFFFAOYSA-M;ZN:B:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N;ACT:C:C2 H3 O2 -1:59.04:ACETATE ION:CC(=O)[O-]:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1:QTBSBXVTEAMEQO-UHFFFAOYSA-M;ZN:C:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N;ACT:D:C2 H3 O2 -1:59.04:ACETATE ION:CC(=O)[O-]:InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1:QTBSBXVTEAMEQO-UHFFFAOYSA-M;ZN:D:Zn 2:65.41:ZINC ION:[Zn+2]:InChI=1S/Zn/q+2:PTFCDOFLOPIGGS-UHFFFAOYSA-N", "description": "They present the crystal structure of Lambda1 AL-T05 with an altered dimer rotated 180\u00c2\u00b0 from the canonical dimer. It shows fast aggregation kinetics."}