{"reference": "J Biol Chem. 2018 Feb 23;293(8):2888-2902.", "alternative_name": "", "entry": "S-0477", "gene_names": "", "remarks": "VGSNKGAIIGL from Amyloid Beta determined by MicroED", "secondary_structure": "VGSNKGAIIGL#CCCCCCCCCCC", "chain_id": "", "inchi": "", "amyloid_non_amyloid": "Amyloid", "pmid": "29282295", "ligand_smiles": "", "keyword": "Amyloid beta A4 protein", "peptide_protein_sequence": "chain-ID A: VGSNKGAIIGL", "uniprot_ac": "P05067", "protein_name": "Amyloid-beta A4 protein", "r_value_free": "0.292", "mutation_s_field": "No", "ligand_mw": "", "pdb_id": "5VOS", "inchi_key": "", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "type": "Fibril", "author": "Krotee, P., Griner, S.L., Sawaya, M.R., Cascio, D., Rodriguez, J.A., Shi, D., Philipp, S., Murray, K., Saelices, L., Lee, J., Seidler, P., Glabe, C.G., Jiang, L., Gonen, T., Eisenberg, D.S.", "species": "Homo sapiens", "ligand_id": "", "method": "ELECTRON CRYSTALLOGRAPHY", "ligand_name": "", "global_stoichiometry": "Homo 10-mer - A10 ", "resolution": "1.42", "ligand_formula": "", "length": "11", "ligstr": "", "description": "[VGSNKGAIIGL fragment from Amyloid Beta] They determined the atomic structures of 11-residue segments from both ABeta and hIAPP, termed ABeta(24-34) WT and hIAPP(19-29) S20G, with 64% sequence similarity. We observed a high degree of structural similarity between their backbone atoms (0.96-A root mean square deviation). Moreover, fibrils of these segments induced amyloid formation through self- and cross-seeding."}