{"method": "X-RAY DIFFRACTION", "mutation_s_field": "No", "ec_number": "", "description": "To uncover the structural origins of two modes of Beta-sheet-rich aggregation (reversible stress granules and irreversible pathogenic amyloid), they have determined ten structures of segments of the LCD of human TDP-43. Six of these segments form steric zippers characteristic of the spines of pathogenic amyloid fibrils; four others form LARKS, the labile amyloid-like interactions characteristic of protein hydrogels and proteins found in membraneless organelles, including stress granules. Segment 396GFNGGFG402 forms a Class 4 steric zipper with face-to-back Beta-sheets and up-down orientation.", "ligstr": "", "pmid": "29786080", "remarks": "Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "1.25", "species": "Homo sapiens", "secondary_structure": "GFNGGFG#CCCCCCC&GFNGGFG#CCCCCCC", "chain_id": "", "gene_names": "", "r_value_free": "0.168", "pdb_id": "5WIQ", "reference": "Nat Struct Mol Biol. 2018 Jun;25(6):463-471.", "keyword": "TAR DNA-binding protein 43", "protein_name": "TAR DNA-binding protein 43", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: GFNGGFG; chain-ID B: GFNGGFG", "entry": "S-0489", "length": "7", "uniprot_ac": "Q13148", "author": "Guenther, E.L., Cao, Q., Trinh, H., Lu, J., Sawaya, M.R., Cascio, D., Boyer, D.R., Rodriguez, J.A., Hughes, M.P., Eisenberg, D.S.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 10-mer - A10", "inchi_key": "", "ligand_id": ""}